Please use this identifier to cite or link to this item:
Title: Vitamin D receptor genetic polymorphysm and osteoporosis
Authors: Henríquez, Manuel Sosa 
Ramírez, Armando Torres
Domínguez Cabrera, Casimira 
Salido, Eduardo
Saavedra Santana, Pedro 
Barrios, Ysamar
Limiñana Cañal, Jose Maria 
León, Pedro Betancor
UNESCO Clasification: 32 Ciencias médicas
3201 Ciencias clínicas
Keywords: Bone-Mineral Density
Postmenopausal Women
Premenopausal Women
Mass, et al
Issue Date: 1998
Journal: Medicina Clínica 
Abstract: BACKGROUND: Genetic factors conditionate an important part of bone mass, The role of vitamin D receptor polymorphism (VDR) as genetic marker of osteoporosis is a matter of discussion. We have studied the possible influence of VDR on bone remodelling, calciotropic hormones, on the presence of osteoporosis and osteoporotic bone fractures.PATIENTS, CONTROL POPULATION AND METHODS: A case-control study. We have studied a total of 127 postmenopausal canarian women from Canary Islands, Spain; 66 healthy controls and 61 with the diagnosis of osteoporosis, which was made by clinical, radiological and densitometric criteria. 17 osteoporotic women have had a fracture: Colles, hip or vertebral (spinal deformity index) fracture. VDR were determined by PCR directed to demonstrate the presence (b) or ausence (B) of a restriction target for Bsml in intron 7. We analized some biochemical markers of bone remodelling: serum levels of alkaline phosphatase, tartrate resistant acid phosphatase and urine ratios of calcium/creatinin and hydroxyproline/creatinin. We also determined calciotropic hormones: parathyroid hormone and calcitonin. Bone mass was measured by DEXA and TC.RESULTS: There were no significant differences in either biochemical bone remodelling markers or in bone mass between the three genotypes: bb, Bb and BE, either in controls or in osteoporotic women with the exception of alkaline phosphatase which had a significative increase compared to control in women with unfavorable alleles distribution (bB and BE). Distribution of genotypes was similar between controls and osteoporotic women, with or without fractures.CONCLUSIONS: In canarian women, VDR genotype is not associated with changes in biochemical markers of bone remodelling or in bone mass or with the presence of osteoporosis or osteoporotic fractures.
ISSN: 0025-7753
Source: Medicina Clinica[ISSN 0025-7753],v. 110, p. 646-650
Appears in Collections:Artículos
Show full item record


checked on Apr 21, 2024


checked on Mar 20, 2022

Page view(s)

checked on Dec 2, 2023

Google ScholarTM



Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.