Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50202
Campo DC Valoridioma
dc.contributor.authorHenríquez, Manuel Sosaen_US
dc.contributor.authorRamírez, Armando Torresen_US
dc.contributor.authorDomínguez Cabrera, Casimiraen_US
dc.contributor.authorSalido, Eduardoen_US
dc.contributor.authorSaavedra Santana, Pedroen_US
dc.contributor.authorBarrios, Ysamaren_US
dc.contributor.authorLimiñana Cañal, Jose Mariaen_US
dc.contributor.authorLeón, Pedro Betancoren_US
dc.date.accessioned2018-11-24T14:10:37Z-
dc.date.available2018-11-24T14:10:37Z-
dc.date.issued1998en_US
dc.identifier.issn0025-7753en_US
dc.identifier.urihttp://hdl.handle.net/10553/50202-
dc.description.abstractBACKGROUND: Genetic factors conditionate an important part of bone mass, The role of vitamin D receptor polymorphism (VDR) as genetic marker of osteoporosis is a matter of discussion. We have studied the possible influence of VDR on bone remodelling, calciotropic hormones, on the presence of osteoporosis and osteoporotic bone fractures.PATIENTS, CONTROL POPULATION AND METHODS: A case-control study. We have studied a total of 127 postmenopausal canarian women from Canary Islands, Spain; 66 healthy controls and 61 with the diagnosis of osteoporosis, which was made by clinical, radiological and densitometric criteria. 17 osteoporotic women have had a fracture: Colles, hip or vertebral (spinal deformity index) fracture. VDR were determined by PCR directed to demonstrate the presence (b) or ausence (B) of a restriction target for Bsml in intron 7. We analized some biochemical markers of bone remodelling: serum levels of alkaline phosphatase, tartrate resistant acid phosphatase and urine ratios of calcium/creatinin and hydroxyproline/creatinin. We also determined calciotropic hormones: parathyroid hormone and calcitonin. Bone mass was measured by DEXA and TC.RESULTS: There were no significant differences in either biochemical bone remodelling markers or in bone mass between the three genotypes: bb, Bb and BE, either in controls or in osteoporotic women with the exception of alkaline phosphatase which had a significative increase compared to control in women with unfavorable alleles distribution (bB and BE). Distribution of genotypes was similar between controls and osteoporotic women, with or without fractures.CONCLUSIONS: In canarian women, VDR genotype is not associated with changes in biochemical markers of bone remodelling or in bone mass or with the presence of osteoporosis or osteoporotic fractures.en_US
dc.languageengen_US
dc.relation.ispartofMedicina Clínicaen_US
dc.sourceMedicina Clinica[ISSN 0025-7753],v. 110, p. 646-650en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherBone-Mineral Densityen_US
dc.subject.otherPostmenopausal Womenen_US
dc.subject.otherPremenopausal Womenen_US
dc.subject.otherComputed-Tomographyen_US
dc.subject.otherMassen_US
dc.subject.otherAllelesen_US
dc.subject.otherGenotypeen_US
dc.subject.otherAssociationen_US
dc.subject.otherSpineen_US
dc.subject.otherDeterminantsen_US
dc.titleVitamin D receptor genetic polymorphysm and osteoporosisen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus0032537271-
dc.identifier.isi000074113000002-
dc.contributor.authorscopusid7003438915-
dc.contributor.authorscopusid7401734920-
dc.contributor.authorscopusid57206303997-
dc.contributor.authorscopusid57206303997-
dc.contributor.authorscopusid14023538500-
dc.contributor.authorscopusid35854556500-
dc.contributor.authorscopusid6701386278-
dc.contributor.authorscopusid7004386478-
dc.contributor.authorscopusid7006146272-
dc.description.lastpage650en_US
dc.description.firstpage646en_US
dc.relation.volume110en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid34942777-
dc.contributor.daisngid1285492-
dc.contributor.daisngid4297253-
dc.contributor.daisngid61141-
dc.contributor.daisngid1515062-
dc.contributor.daisngid21687494-
dc.contributor.daisngid2555805-
dc.contributor.daisngid1657471-
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Henriquez, MS-
dc.contributor.wosstandardWOS:Ramirez, AT-
dc.contributor.wosstandardWOS:Cabrera, CD-
dc.contributor.wosstandardWOS:Salido, E-
dc.contributor.wosstandardWOS:Santana, PS-
dc.contributor.wosstandardWOS:Barrios, Y-
dc.contributor.wosstandardWOS:Canal, JML-
dc.contributor.wosstandardWOS:Leon, PB-
dc.date.coverdateMayo 1998en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr0,789-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.orcid0000-0003-1681-7165-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameSosa Henríquez,Manuel José-
crisitem.author.fullNameDomínguez Cabrera, Casimira-
crisitem.author.fullNameSaavedra Santana, Pedro-
crisitem.author.fullNameLimiñana Cañal, Jose Maria-
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