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Title: | Atypical carcinoid tumours of the lung: Prognostic factors and patterns of recurrence | Authors: | Cañizares, Miguel A. Matilla, J. M. Cueto, A. Algar, J. Muguruza, I. Moreno-Mata, N. Moreno-Balsalobre, R. Guijarro, R. Arrabal, R. Garcia-Fontan, E. Gonzalez-Pinẽiro, A. Garcia-Yuste, M. Matilla, Jose Maria Heras, Felix Borrego, Henar Escobar, Ignacio Moya, Joan Lago, Juan Saldaña, David Garrido, Pilar Cerezo, Francisco Gonzalez-Aragoneses, Federico Simon, Carlos Alvarez, Emilio Cebollero, Maria Rodriguez-Paniagua, Jose Manuel Arnau, Antonio Lopez-Rivero, Luis Quevedo, Santiago Camacho, Maria Carmen Astudillo, Julio Perez, Javier Molins, Laureano Mier, Jose Manuel Sanchez-Palencia, Abel Concha, Angel Freixinet, Jorge Rodriguez, Pedro Romero, Teresa Torres, Juan Bermejo, Juan Moreno, Nicolas Blanco, Ana Borro, Jose Maria De-la-Torre, Mercedes Capdevilla, Ana Moreno, Ramon Serra, Mireia Rami-Porta, Ramon Benitez, Antonio Varela, Andres Cordoba, Mar Blanco-Ramos, Montserrat Zapatero, José Rivas, Juan Jose Menal, Patricia Galan, Genaro Ansotegui, Emilio |
UNESCO Clasification: | 32 Ciencias médicas 320713 Oncología |
Keywords: | Carcinoid tumours Lung Neoplasm |
Issue Date: | 2014 | Journal: | Thorax | Abstract: | Background Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome. | URI: | http://hdl.handle.net/10553/50156 | ISSN: | 0040-6376 | DOI: | 10.1136/thoraxjnl-2013-204102 | Source: | Thorax[ISSN 0040-6376],v. 69, p. 648-653 (Junio 2014) |
Appears in Collections: | Artículos |
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