|Title:||Atypical carcinoid tumours of the lung: Prognostic factors and patterns of recurrence||Authors:||Cañizares, Miguel A.
Matilla, J. M.
Matilla, Jose Maria
Rodriguez-Paniagua, Jose Manuel
Camacho, Maria Carmen
Mier, Jose Manuel
Borro, Jose Maria
Rivas, Juan Jose
|UNESCO Clasification:||32 Ciencias médicas
|Issue Date:||2014||Journal:||Thorax||Abstract:||Background Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome.||URI:||http://hdl.handle.net/10553/50156||ISSN:||0040-6376||DOI:||10.1136/thoraxjnl-2013-204102||Source:||Thorax[ISSN 0040-6376],v. 69, p. 648-653 (Junio 2014)|
|Appears in Collections:||Artículos|
checked on Sep 24, 2023
checked on Apr 22, 2023
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.