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Title: In vitro selected fluoroquinolone-resistant mutants of Citrobacter freundii: Analysis of the quinolone resistance acquisition
Authors: Del Mar Tavío, María 
Vila, Jordi
Ruiz, Joaquím
Amicosante, Gianfranco
Franceschini, Nicola
Martín-Sánchez, Antonio M. 
Jiménez De Anta, María Teresa
Keywords: Escherichia-Coli
Issue Date: 2000
Publisher: 0305-7453
Journal: Journal of Antimicrobial Chemotherapy 
Abstract: Ten quinolone-resistant mutants of Citrobacter freundii, which were selected in vitro with fluoroquinolones from two clinical isolates, were studied. The parent isolates were susceptible to quinolones in spite of showing a single substitution in the GyrB (His-417 --> Leu). No change was observed in the outer membrane proteins or in the lipopolysaccharide in any of the ten mutants studied with respect to their parent isolates. The development of quinolone resistance in selected mutants was associated with the appearance of a substitution in the GyrA (Thr-83 --> Ile) in nine of the ten mutants plus enhanced active efflux in all of them.
ISSN: 0305-7453
Source: Journal of Antimicrobial Chemotherapy[ISSN 0305-7453],v. 45, p. 521-524
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