Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49973
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dc.contributor.authorDel Mar Tavío, María
dc.contributor.authorVila, Jordi
dc.contributor.authorRuiz, Joaquím
dc.contributor.authorAmicosante, Gianfranco
dc.contributor.authorFranceschini, Nicola
dc.contributor.authorMartín-Sánchez, Antonio M.
dc.contributor.authorJiménez De Anta, María Teresa
dc.date.accessioned2018-11-24T12:14:15Z-
dc.date.available2018-11-24T12:14:15Z-
dc.date.issued2000
dc.identifier.issn0305-7453
dc.identifier.urihttp://hdl.handle.net/10553/49973-
dc.description.abstractTen quinolone-resistant mutants of Citrobacter freundii, which were selected in vitro with fluoroquinolones from two clinical isolates, were studied. The parent isolates were susceptible to quinolones in spite of showing a single substitution in the GyrB (His-417 --> Leu). No change was observed in the outer membrane proteins or in the lipopolysaccharide in any of the ten mutants studied with respect to their parent isolates. The development of quinolone resistance in selected mutants was associated with the appearance of a substitution in the GyrA (Thr-83 --> Ile) in nine of the ten mutants plus enhanced active efflux in all of them.
dc.publisher0305-7453
dc.relation.ispartofJournal of Antimicrobial Chemotherapy
dc.sourceJournal of Antimicrobial Chemotherapy[ISSN 0305-7453],v. 45, p. 521-524
dc.subject.otherEscherichia-Coli
dc.subject.otherMutations
dc.titleIn vitro selected fluoroquinolone-resistant mutants of Citrobacter freundii: Analysis of the quinolone resistance acquisition
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.scopus0034114295
dc.identifier.isi000086537500016
dc.contributor.authorscopusid6701659492
dc.contributor.authorscopusid7202012753
dc.contributor.authorscopusid35392400000
dc.contributor.authorscopusid7006729208
dc.contributor.authorscopusid7006270914
dc.contributor.authorscopusid7005670807
dc.contributor.authorscopusid35412061700
dc.description.lastpage524
dc.description.firstpage521
dc.relation.volume45
dc.type2Artículoes
dc.contributor.daisngid9058102
dc.contributor.daisngid24031
dc.contributor.daisngid173728
dc.contributor.daisngid144499
dc.contributor.daisngid651911
dc.contributor.daisngid1842149
dc.contributor.daisngid459288
dc.contributor.wosstandardWOS:Tavio, MD
dc.contributor.wosstandardWOS:Vila, J
dc.contributor.wosstandardWOS:Ruiz, J
dc.contributor.wosstandardWOS:Amicosante, G
dc.contributor.wosstandardWOS:Franceschini, N
dc.contributor.wosstandardWOS:Martin-Sanchez, AM
dc.contributor.wosstandardWOS:de Anta, MTJ
dc.date.coverdateAbril 2000
dc.identifier.ulpgces
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptEpidemiología y Medicina Preventiva Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameTavío Pérez, María Del Mar-
crisitem.author.fullNameMartín Sánchez, Antonio Manuel-
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