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Title: Mechanisms involved in quinolone resistance in Mycoplasma mycoides subsp. capri
Authors: Antunes, Nuno T.
Assunção, Patrícia
Poveda, Jose B. 
Tavío, María M. 
Keywords: In-Vitro Susceptibilities
Efflux-Mediated Resistance
Dna Gyrase
Fluoroquinolone Resistance
Topoisomerase-Iv, et al
Issue Date: 2015
Publisher: 1090-0233
Journal: Veterinary Journal 
Abstract: Mycoplasma mycoides subsp. capri is a causative agent of contagious agalactia in goats. In this study, M. mycoides subsp. capri mutants were selected for resistance to fluoroquinolones (norfloxacin, enrofloxacin and ciprofloxacin) by serial passes in broth with increasing concentrations of antibiotic. Mutations conferring cross-resistance to the three fluoroquinolones were found in the quinolone resistance determining regions of the four genes encoding DNA gyrase and topoisomerase IV. Different mutations in the DNA gyrase GyrA subunit suggest a different mechanism of inhibition between norfloxacin and the other tested fluoroquinolones. The presence of an adenosine triphosphate-dependent efflux system was suggested through the use of the inhibitor orthovanadate. (C) 2015 Elsevier Ltd. All rights reserved.
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2015.04.018
Source: Veterinary Journal[ISSN 1090-0233],v. 204 (3), p. 327-332
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