Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49956
DC FieldValueLanguage
dc.contributor.authorAntunes, Nuno T.
dc.contributor.authorAssunção, Patrícia
dc.contributor.authorPoveda, Jose B.
dc.contributor.authorTavío, María M.
dc.contributor.otherPoveda, Jose
dc.date.accessioned2018-11-24T12:06:16Z-
dc.date.available2018-11-24T12:06:16Z-
dc.date.issued2015
dc.identifier.issn1090-0233
dc.identifier.urihttp://hdl.handle.net/10553/49956-
dc.description.abstractMycoplasma mycoides subsp. capri is a causative agent of contagious agalactia in goats. In this study, M. mycoides subsp. capri mutants were selected for resistance to fluoroquinolones (norfloxacin, enrofloxacin and ciprofloxacin) by serial passes in broth with increasing concentrations of antibiotic. Mutations conferring cross-resistance to the three fluoroquinolones were found in the quinolone resistance determining regions of the four genes encoding DNA gyrase and topoisomerase IV. Different mutations in the DNA gyrase GyrA subunit suggest a different mechanism of inhibition between norfloxacin and the other tested fluoroquinolones. The presence of an adenosine triphosphate-dependent efflux system was suggested through the use of the inhibitor orthovanadate. (C) 2015 Elsevier Ltd. All rights reserved.
dc.publisher1090-0233
dc.relation.ispartofVeterinary Journal
dc.sourceVeterinary Journal[ISSN 1090-0233],v. 204 (3), p. 327-332
dc.subject.otherIn-Vitro Susceptibilities
dc.subject.otherEfflux-Mediated Resistance
dc.subject.otherDna Gyrase
dc.subject.otherFluoroquinolone Resistance
dc.subject.otherTopoisomerase-Iv
dc.subject.otherContagious Agalactia
dc.subject.otherEthidium-Bromide
dc.subject.otherHominis
dc.subject.otherMutations
dc.subject.otherMutants
dc.titleMechanisms involved in quinolone resistance in Mycoplasma mycoides subsp. capri
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.tvjl.2015.04.018
dc.identifier.scopus84929653113
dc.identifier.isi000356554800017
dcterms.isPartOfVeterinary Journal
dcterms.sourceVeterinary Journal[ISSN 1090-0233],v. 204 (3), p. 327-332
dc.contributor.authorscopusid57196635499
dc.contributor.authorscopusid6701838348
dc.contributor.authorscopusid7005736558
dc.contributor.authorscopusid6701659492
dc.description.lastpage332
dc.description.firstpage327
dc.relation.volume204
dc.type2Artículoes
dc.identifier.wosWOS:000356554800017
dc.contributor.daisngid1398738
dc.contributor.daisngid1211232
dc.contributor.daisngid498394
dc.contributor.daisngid2590173
dc.identifier.investigatorRIDL-5987-2014
dc.contributor.wosstandardWOS:Antunes, NT
dc.contributor.wosstandardWOS:Assuncao, P
dc.contributor.wosstandardWOS:Poveda, JB
dc.contributor.wosstandardWOS:Tavio, MM
dc.date.coverdateJunio 2015
dc.identifier.ulpgces
dc.description.sjr0,95
dc.description.jcr1,68
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Investigación Básica y Aplicada en Ciencias de la Salud-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9846-2427-
crisitem.author.orcid0000-0002-1808-7461-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgDepartamento de Ciencias Clínicas-
crisitem.author.fullNamePoveda Guerrero, José Bismarck-
crisitem.author.fullNameTavío Pérez, María Del Mar-
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