Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49723
Title: Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes
Authors: D'Alessio, David
Häring, H. U.
Charbonnel, B.
de Pablos-Velasco, P. 
Candelas, C.
Dain, M. P.
Vincent, M.
Pilorget, V.
Yki-Järvinen, H.
Keywords: To-Target Trial
Clinical Inertia
Exenatide
Glucose
Rosiglitazone
Lixisenatide
Metaanalysis
Glyburide
Therapies
Metformin
Issue Date: 2015
Publisher: 1462-8902
Journal: Diabetes, Obesity and Metabolism 
Abstract: AimTo compare safety and efficacy of insulin glargine and liraglutide in patients with type 2 diabetes (T2DM).MethodsThis randomized, multinational, open-label trial included subjects treated for T2DM with metforminsulphonylurea, who had glycated haemoglobin (HbA1c) levels of 7.5-12%. Subjects were assigned to 24weeks of insulin glargine, titrated to target fasting plasma glucose of 4.0-5.5mmol/L or liraglutide, escalated to the highest approved clinical dose of 1.8mg daily. The trial was powered to detect superiority of glargine over liraglutide in percentage of people reaching HbA1c <7%.ResultsThe mean [standard deviation (s.d.)] age of the participants was 57 (9)years, the duration of diabetes was 9 (6)years, body mass index was 31.9 (4.2)kg/m(2) and HbA1c level was 9.0 (1.1)%. Equal numbers (n=489) were allocated to glargine and liraglutide. Similar numbers of subjects in both groups attained an HbA1c level of <7% (48.4 vs. 45.9%); therefore, superiority of glargine over liraglutide was not observed (p=0.44). Subjects treated with glargine had greater reductions of HbA1c [-1.94% (0.05) and -1.79% (0.05); p=0.019] and fasting plasma glucose [6.2 (1.6) and 7.9 (2.2) mmol/L; p<0.001] than those receiving liraglutide. The liraglutide group reported a greater number of gastrointestinal treatment-emergent adverse events (p<0.001). The mean (s.d.) weight change was +2.0 (4.0)kg for glargine and -3.0 (3.6)kg for liraglutide (p<0.001). Symptomatic hypoglycaemia was more common with glargine (p<0.001). A greater number of subjects in the liraglutide arm withdrew as a result of adverse events (p<0.001).ConclusionAdding either insulin glargine or liraglutide to subjects with poorly controlled T2DM reduces HbA1c substantially, with nearly half of subjects reaching target levels of 7%.
URI: http://hdl.handle.net/10553/49723
ISSN: 1462-8902
DOI: 10.1111/dom.12406
Source: Diabetes, Obesity and Metabolism[ISSN 1462-8902],v. 17, p. 170-178
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