Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49723
Title: Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes
Authors: D'Alessio, David
Häring, H. U.
Charbonnel, B.
de Pablos-Velasco, P. 
Candelas, C.
Dain, M. P.
Vincent, M.
Pilorget, V.
Yki-Järvinen, H.
UNESCO Clasification: 32 Ciencias médicas
3205 Medicina interna
Keywords: To-Target Trial
Clinical Inertia
Exenatide
Glucose
Rosiglitazone, et al
Issue Date: 2015
Journal: Diabetes, Obesity and Metabolism 
Abstract: AimTo compare safety and efficacy of insulin glargine and liraglutide in patients with type 2 diabetes (T2DM).MethodsThis randomized, multinational, open-label trial included subjects treated for T2DM with metforminsulphonylurea, who had glycated haemoglobin (HbA1c) levels of 7.5-12%. Subjects were assigned to 24weeks of insulin glargine, titrated to target fasting plasma glucose of 4.0-5.5mmol/L or liraglutide, escalated to the highest approved clinical dose of 1.8mg daily. The trial was powered to detect superiority of glargine over liraglutide in percentage of people reaching HbA1c <7%.ResultsThe mean [standard deviation (s.d.)] age of the participants was 57 (9)years, the duration of diabetes was 9 (6)years, body mass index was 31.9 (4.2)kg/m(2) and HbA1c level was 9.0 (1.1)%. Equal numbers (n=489) were allocated to glargine and liraglutide. Similar numbers of subjects in both groups attained an HbA1c level of <7% (48.4 vs. 45.9%); therefore, superiority of glargine over liraglutide was not observed (p=0.44). Subjects treated with glargine had greater reductions of HbA1c [-1.94% (0.05) and -1.79% (0.05); p=0.019] and fasting plasma glucose [6.2 (1.6) and 7.9 (2.2) mmol/L; p<0.001] than those receiving liraglutide. The liraglutide group reported a greater number of gastrointestinal treatment-emergent adverse events (p<0.001). The mean (s.d.) weight change was +2.0 (4.0)kg for glargine and -3.0 (3.6)kg for liraglutide (p<0.001). Symptomatic hypoglycaemia was more common with glargine (p<0.001). A greater number of subjects in the liraglutide arm withdrew as a result of adverse events (p<0.001).ConclusionAdding either insulin glargine or liraglutide to subjects with poorly controlled T2DM reduces HbA1c substantially, with nearly half of subjects reaching target levels of 7%.
URI: http://hdl.handle.net/10553/49723
ISSN: 1462-8902
DOI: 10.1111/dom.12406
Source: Diabetes, Obesity and Metabolism[ISSN 1462-8902],v. 17, p. 170-178 (Febrero 2015)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

35
checked on Mar 24, 2024

WEB OF SCIENCETM
Citations

33
checked on Feb 25, 2024

Page view(s)

31
checked on Oct 14, 2023

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.