Please use this identifier to cite or link to this item:
Title: Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population
Authors: Garcia-Laorden, M. Isabel
Pena, M. Jose
Caminero Luna, José Antonio 
Garcia-Saavedra, Ayoze
Campos-Herrero, M. Isolina 
Caballero, Araceli
Rodriguez-Gallego, Carlos 
UNESCO Clasification: 32 Ciencias médicas
2302 Bioquímica
Keywords: Tuberculosis
Issue Date: 2006
Journal: Molecular Immunology 
Abstract: Mannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. Its deficiency has been associated with increased susceptibility to infectious diseases, mainly in childhood. However, non-producer mbl-2 alleles are common in most populations, suggesting a selective advantage of these alleles. We have analysed the association of mbl-2 structural and promoter polymorphisms with HIV infection and tuberculosis (TBC) in a white Spanish population, including 615 HIV patients with and without TBC, 127 no-HIV TBC patients, 142 TBC household contacts and 344 controls. The frequency of low or non-producer mbl-2 genotypes was lower in HIV patients than in controls. HIV-TBC patients presented lower frequencies of low or non-producer alleles and genotypes than HIV no-TBC patients and controls. Additionally, we found a significantly positive correlation between the incidence of TBC and the frequency of non-producer mbl-2 alleles in Western Europe. Therefore, MBL deficiency may be associated with a lower risk of HIV infection, and also of active TBC, at least in HIV patients. The protective role of low-producer mbl-2 genotypes against TBC together with the positive correlation observed between non-producer mbl-2 alleles and TBC incidence, suggest a balancing selection: in spite of an increased susceptibility to respiratory infections associated with MBL deficiency, mbl-2 deficient alleles would have been selected along different populations as a consequence of its selective advantage against intracellular pathogens, such as M. tuberculosis.
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2006.01.008
Source: Molecular Immunology[ISSN 0161-5890],v. 43, p. 2143-2150 (Julio 2006)
Appears in Collections:Artículos
Show full item record


checked on Sep 24, 2023

Page view(s)

checked on Aug 12, 2023

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.