Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48638
Campo DC Valoridioma
dc.contributor.authorGarcia-Laorden, M. Isabelen_US
dc.contributor.authorPena, M. Joseen_US
dc.contributor.authorCaminero Luna, José Antonioen_US
dc.contributor.authorGarcia-Saavedra, Ayozeen_US
dc.contributor.authorCampos-Herrero, M. Isolinaen_US
dc.contributor.authorCaballero, Aracelien_US
dc.contributor.authorRodriguez-Gallego, Carlosen_US
dc.date.accessioned2018-11-23T23:37:58Z-
dc.date.available2018-11-23T23:37:58Z-
dc.date.issued2006en_US
dc.identifier.issn0161-5890en_US
dc.identifier.urihttp://hdl.handle.net/10553/48638-
dc.description.abstractMannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. Its deficiency has been associated with increased susceptibility to infectious diseases, mainly in childhood. However, non-producer mbl-2 alleles are common in most populations, suggesting a selective advantage of these alleles. We have analysed the association of mbl-2 structural and promoter polymorphisms with HIV infection and tuberculosis (TBC) in a white Spanish population, including 615 HIV patients with and without TBC, 127 no-HIV TBC patients, 142 TBC household contacts and 344 controls. The frequency of low or non-producer mbl-2 genotypes was lower in HIV patients than in controls. HIV-TBC patients presented lower frequencies of low or non-producer alleles and genotypes than HIV no-TBC patients and controls. Additionally, we found a significantly positive correlation between the incidence of TBC and the frequency of non-producer mbl-2 alleles in Western Europe. Therefore, MBL deficiency may be associated with a lower risk of HIV infection, and also of active TBC, at least in HIV patients. The protective role of low-producer mbl-2 genotypes against TBC together with the positive correlation observed between non-producer mbl-2 alleles and TBC incidence, suggest a balancing selection: in spite of an increased susceptibility to respiratory infections associated with MBL deficiency, mbl-2 deficient alleles would have been selected along different populations as a consequence of its selective advantage against intracellular pathogens, such as M. tuberculosis.en_US
dc.languageengen_US
dc.relation.ispartofMolecular Immunologyen_US
dc.sourceMolecular Immunology[ISSN 0161-5890],v. 43, p. 2143-2150 (Julio 2006)en_US
dc.subject32 Ciencias médicasen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherTuberculosisen_US
dc.subject.otherHIVen_US
dc.subject.otherGenotypeen_US
dc.titleInfluence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European populationen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.molimm.2006.01.008en_US
dc.identifier.scopus33744826814-
dc.contributor.authorscopusid6506073949-
dc.contributor.authorscopusid7101969201-
dc.contributor.authorscopusid57188992735-
dc.contributor.authorscopusid13408676500-
dc.contributor.authorscopusid6603084722-
dc.contributor.authorscopusid12774686300-
dc.contributor.authorscopusid6602114379-
dc.description.lastpage2150en_US
dc.description.firstpage2143en_US
dc.relation.volume43en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateJulio 2006en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr4,768-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2931-9483-
crisitem.author.orcid0000-0002-1310-3354-
crisitem.author.orcid0000-0002-4344-8644-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCaminero Luna, José Antonio-
crisitem.author.fullNameCampos Herrero Navas,María Isolina-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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