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Title: Biochemical markers of bone formation in the study of postmenopausal osteoporosis
Authors: Dominguez Cabrera, C. 
Sosa Henríquez, M. 
Traba, M. L.
Alvarez Villafañe, E.
De La Piedra, C.
UNESCO Clasification: 32 Ciencias médicas
320714 Osteopatología
Keywords: Alkaline phosphatase
Aminoterminal procollagen
Carboxyterminal procollagen
Postmenopausal osteoporosis
Issue Date: 1998
Journal: Osteoporosis International 
Abstract: A comparative study was performed on the sensitivity of the determination of the available biochemical markers of bone formation--total and bone alkaline phosphatase (TAP and bAP, respectively), osteocalcin (BGP), procollagen I aminoterminal propeptide (PINP) and procollagen I carboxyterminal propeptide (PICP)--in the study of postmenopausal osteoporosis. The comparison between PINP and PICP, due to the recent development of the amino-terminal assay, is of special interest. The study included 26 untreated osteoporotic postmenopausal women, age 59 +/- 6 years (range 46-69 years) and 17 healty control postmenopausal women, age 56 +/- 7 years (range 48-70 years). We found a significant increase in the levels of bAP (p = 0.0021), BGP (p = 0.041), PINP (p = 0.0001) and PCIP (p = 0.0073), but not in the levels of TAP (p = 0.3389), in osteoporotic patients with respect to the control group. Serum PINP and bAP showed the highest diagnostic accuracy among the markers of bone formation studies, as can be deduced from the receiver operating characteristics (ROC) curves. In spite of their similar origin (amino-terminal and carboxy-terminal release from a procollagen molecule), the results obtained by measuring levels of PINP are significantly better than those found with PICP.
ISSN: 0937-941X
DOI: 10.1007/BF02672511
Source: Osteoporosis International [ISSN 0937-941X], v. 8, p. 147-151 (Febrero 1998)
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