Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48570
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dc.contributor.authorDominguez Cabrera, C.en_US
dc.contributor.authorSosa Henríquez, M.en_US
dc.contributor.authorTraba, M. L.en_US
dc.contributor.authorAlvarez Villafañe, E.en_US
dc.contributor.authorDe La Piedra, C.en_US
dc.date.accessioned2018-11-23T22:58:59Z-
dc.date.available2018-11-23T22:58:59Z-
dc.date.issued1998en_US
dc.identifier.issn0937-941Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/48570-
dc.description.abstractA comparative study was performed on the sensitivity of the determination of the available biochemical markers of bone formation--total and bone alkaline phosphatase (TAP and bAP, respectively), osteocalcin (BGP), procollagen I aminoterminal propeptide (PINP) and procollagen I carboxyterminal propeptide (PICP)--in the study of postmenopausal osteoporosis. The comparison between PINP and PICP, due to the recent development of the amino-terminal assay, is of special interest. The study included 26 untreated osteoporotic postmenopausal women, age 59 +/- 6 years (range 46-69 years) and 17 healty control postmenopausal women, age 56 +/- 7 years (range 48-70 years). We found a significant increase in the levels of bAP (p = 0.0021), BGP (p = 0.041), PINP (p = 0.0001) and PCIP (p = 0.0073), but not in the levels of TAP (p = 0.3389), in osteoporotic patients with respect to the control group. Serum PINP and bAP showed the highest diagnostic accuracy among the markers of bone formation studies, as can be deduced from the receiver operating characteristics (ROC) curves. In spite of their similar origin (amino-terminal and carboxy-terminal release from a procollagen molecule), the results obtained by measuring levels of PINP are significantly better than those found with PICP.en_US
dc.languageengen_US
dc.relation.ispartofOsteoporosis Internationalen_US
dc.sourceOsteoporosis International [ISSN 0937-941X], v. 8, p. 147-151 (Febrero 1998)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320714 Osteopatologíaen_US
dc.subject.otherAlkaline phosphataseen_US
dc.subject.otherAminoterminal procollagenen_US
dc.subject.otherCarboxyterminal procollagenen_US
dc.subject.otherOsteocalcinen_US
dc.subject.otherPostmenopausal osteoporosisen_US
dc.titleBiochemical markers of bone formation in the study of postmenopausal osteoporosisen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/BF02672511en_US
dc.identifier.scopus0031982325-
dc.contributor.authorscopusid6508329787-
dc.contributor.authorscopusid7004134221-
dc.contributor.authorscopusid7003263927-
dc.contributor.authorscopusid6507521364-
dc.contributor.authorscopusid7006852587-
dc.description.lastpage151en_US
dc.description.firstpage147en_US
dc.relation.volume8en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.date.coverdateFebrero 1998en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,475-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameDomínguez Cabrera, Casimira-
crisitem.author.fullNameSosa Henríquez,Manuel José-
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