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Title: | Ezrin mediates c-Myc actions in prostate cancer cell invasion | Authors: | Chuan, Y. C. Iglesias-Gato, D. Fernandez-Perez, L. Cedazo-Minguez, A. Pang, S. T. Norstedt, G. Pousette, Å Flores-Morales, A. |
UNESCO Clasification: | 32 Ciencias médicas 320101 Oncología |
Keywords: | Androgen Receptor Gene-Expression Akt Activity In-Vivo Progression, et al |
Issue Date: | 2010 | Journal: | Oncogene | Abstract: | The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3 beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells. | URI: | http://hdl.handle.net/10553/48253 | ISSN: | 0950-9232 | DOI: | 10.1038/onc.2009.442 | Source: | Oncogene[ISSN 0950-9232],v. 29, p. 1531-1542 |
Appears in Collections: | Artículos |
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