Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48253
Title: Ezrin mediates c-Myc actions in prostate cancer cell invasion
Authors: Chuan, Y. C.
Iglesias-Gato, D.
Fernandez-Perez, L. 
Cedazo-Minguez, A.
Pang, S. T.
Norstedt, G.
Pousette, Å
Flores-Morales, A. 
UNESCO Clasification: 32 Ciencias médicas
320101 Oncología
Keywords: Androgen Receptor
Gene-Expression
Akt Activity
In-Vivo
Progression, et al
Issue Date: 2010
Journal: Oncogene 
Abstract: The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3 beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells.
URI: http://hdl.handle.net/10553/48253
ISSN: 0950-9232
DOI: 10.1038/onc.2009.442
Source: Oncogene[ISSN 0950-9232],v. 29, p. 1531-1542
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