Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48253
Campo DC Valoridioma
dc.contributor.authorChuan, Y. C.en_US
dc.contributor.authorIglesias-Gato, D.en_US
dc.contributor.authorFernandez-Perez, L.en_US
dc.contributor.authorCedazo-Minguez, A.en_US
dc.contributor.authorPang, S. T.en_US
dc.contributor.authorNorstedt, G.en_US
dc.contributor.authorPousette, Åen_US
dc.contributor.authorFlores-Morales, A.en_US
dc.date.accessioned2018-11-23T20:10:34Z-
dc.date.available2018-11-23T20:10:34Z-
dc.date.issued2010en_US
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://hdl.handle.net/10553/48253-
dc.description.abstractThe forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3 beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells.en_US
dc.languageengen_US
dc.relation.ispartofOncogeneen_US
dc.sourceOncogene[ISSN 0950-9232],v. 29, p. 1531-1542en_US
dc.subject32 Ciencias médicasen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherAndrogen Receptoren_US
dc.subject.otherGene-Expressionen_US
dc.subject.otherAkt Activityen_US
dc.subject.otherIn-Vivoen_US
dc.subject.otherProgressionen_US
dc.subject.otherActivationen_US
dc.subject.otherSuppressoren_US
dc.subject.otherPathwaysen_US
dc.subject.otherGrowthen_US
dc.subject.otherPtenen_US
dc.titleEzrin mediates c-Myc actions in prostate cancer cell invasionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/onc.2009.442en_US
dc.identifier.scopus77949423269-
dc.identifier.isi000275392400011-
dc.contributor.authorscopusid8325409300-
dc.contributor.authorscopusid36664682600-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid57206230472-
dc.contributor.authorscopusid6603612017-
dc.contributor.authorscopusid7402528885-
dc.contributor.authorscopusid7006397634-
dc.contributor.authorscopusid7004969713-
dc.contributor.authorscopusid57203543352-
dc.description.lastpage1542en_US
dc.description.firstpage1531en_US
dc.relation.volume29en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid4244439-
dc.contributor.daisngid2567702-
dc.contributor.daisngid795544-
dc.contributor.daisngid415301-
dc.contributor.daisngid218357-
dc.contributor.daisngid178539-
dc.contributor.daisngid28136248-
dc.contributor.daisngid617657-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Chuan, YC-
dc.contributor.wosstandardWOS:Iglesias-Gato, D-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Cedazo-Minguez, A-
dc.contributor.wosstandardWOS:Pang, ST-
dc.contributor.wosstandardWOS:Norstedt, G-
dc.contributor.wosstandardWOS:Pousette, A-
dc.contributor.wosstandardWOS:Flores-Morales, A-
dc.date.coverdateMarzo 2010en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr7,414-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0828-8921-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.author.fullNameFlores Morales,Amilcar-
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