Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/48253
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Chuan, Y. C. | en_US |
dc.contributor.author | Iglesias-Gato, D. | en_US |
dc.contributor.author | Fernandez-Perez, L. | en_US |
dc.contributor.author | Cedazo-Minguez, A. | en_US |
dc.contributor.author | Pang, S. T. | en_US |
dc.contributor.author | Norstedt, G. | en_US |
dc.contributor.author | Pousette, Å | en_US |
dc.contributor.author | Flores-Morales, A. | en_US |
dc.date.accessioned | 2018-11-23T20:10:34Z | - |
dc.date.available | 2018-11-23T20:10:34Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.issn | 0950-9232 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/48253 | - |
dc.description.abstract | The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3 beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Oncogene | en_US |
dc.source | Oncogene[ISSN 0950-9232],v. 29, p. 1531-1542 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 320101 Oncología | en_US |
dc.subject.other | Androgen Receptor | en_US |
dc.subject.other | Gene-Expression | en_US |
dc.subject.other | Akt Activity | en_US |
dc.subject.other | In-Vivo | en_US |
dc.subject.other | Progression | en_US |
dc.subject.other | Activation | en_US |
dc.subject.other | Suppressor | en_US |
dc.subject.other | Pathways | en_US |
dc.subject.other | Growth | en_US |
dc.subject.other | Pten | en_US |
dc.title | Ezrin mediates c-Myc actions in prostate cancer cell invasion | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/onc.2009.442 | en_US |
dc.identifier.scopus | 77949423269 | - |
dc.identifier.isi | 000275392400011 | - |
dc.contributor.authorscopusid | 8325409300 | - |
dc.contributor.authorscopusid | 36664682600 | - |
dc.contributor.authorscopusid | 6506777525 | - |
dc.contributor.authorscopusid | 57206230472 | - |
dc.contributor.authorscopusid | 6603612017 | - |
dc.contributor.authorscopusid | 7402528885 | - |
dc.contributor.authorscopusid | 7006397634 | - |
dc.contributor.authorscopusid | 7004969713 | - |
dc.contributor.authorscopusid | 57203543352 | - |
dc.description.lastpage | 1542 | en_US |
dc.description.firstpage | 1531 | en_US |
dc.relation.volume | 29 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 4244439 | - |
dc.contributor.daisngid | 2567702 | - |
dc.contributor.daisngid | 795544 | - |
dc.contributor.daisngid | 415301 | - |
dc.contributor.daisngid | 218357 | - |
dc.contributor.daisngid | 178539 | - |
dc.contributor.daisngid | 28136248 | - |
dc.contributor.daisngid | 617657 | - |
dc.description.numberofpages | 12 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Chuan, YC | - |
dc.contributor.wosstandard | WOS:Iglesias-Gato, D | - |
dc.contributor.wosstandard | WOS:Fernandez-Perez, L | - |
dc.contributor.wosstandard | WOS:Cedazo-Minguez, A | - |
dc.contributor.wosstandard | WOS:Pang, ST | - |
dc.contributor.wosstandard | WOS:Norstedt, G | - |
dc.contributor.wosstandard | WOS:Pousette, A | - |
dc.contributor.wosstandard | WOS:Flores-Morales, A | - |
dc.date.coverdate | Marzo 2010 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 7,414 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0001-7802-465X | - |
crisitem.author.orcid | 0000-0002-0828-8921 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
crisitem.author.fullName | Flores Morales,Amilcar | - |
Colección: | Artículos |
Citas SCOPUSTM
59
actualizado el 10-nov-2024
Citas de WEB OF SCIENCETM
Citations
56
actualizado el 10-nov-2024
Visitas
80
actualizado el 26-oct-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.