Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48252
Title: Synthesis and in vitro antiprotozoal evaluation of substituted phenalenone analogues
Authors: Rosquete, Laura I.
Cabrera-Serra, M. Gabriela
Piñero, José E.
Martin-Rodriguez, Patricia 
Fernández-Pérez, Leandro 
Luis, Javier G.
McNaughton-Smith, Grant
Abad-Grillo, Teresa
UNESCO Clasification: 32 Ciencias médicas
230207 Química clínica
Keywords: Magnesium Exchange-Reaction
Musa-Acuminata
Singlet Oxygen
Ate Complex
Phytoalexins, et al
Issue Date: 2010
Journal: Bioorganic and Medicinal Chemistry 
Abstract: A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiparasitic activities against the most clinically relevant forms of trypanosomiasis and leishmaniasis. Several compounds exhibited leishmanicidal effects at levels comparable or better than the reference drug pentamidine, while the parent phenalenone was shown to have a level of activity against Trypanosoma cruzi comparable to the marketed drug benznidazole.
URI: http://hdl.handle.net/10553/48252
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2010.04.062
Source: Bioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 18 (12), p. 4530-4534
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