Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47744
Title: Effect of cervical spinal cord stimulation on regional blood flow and oxygenation in advanced head and neck tumours
Authors: Clavo, Bernardino 
Robaina, F.
Catalá, L.
Pérez, J. L.
Lloret, M.
Caramés, M. Á 
Morera, J.
López, L.
Suárez, G.
Macías, D.
Rivero, J.
Hernández, M. A.
UNESCO Clasification: 32 Ciencias médicas
320713 Oncología
Keywords: Blood flow
Colour Doppler
Head & neck cancer
Spinal cord stimulation
Transcranial Doppler, et al
Issue Date: 2004
Journal: Annals of Oncology 
Abstract: Background: Tumour ischaemia leads to decreased delivery of oxygen, chemotherapy and radiosensitisers. Hypoxia in head and neck (H&N) tumours is an important adverse prognostic factor. Spinal cord stimulation (SCS) is a well-established neurosurgical technique in the treatment of several ischaemic syndromes. This prospective study evaluated the effect of cervical-SCS on common carotid artery (CCA) blood flow and tumour oxygenation in patients with advanced H&N cancer. Patients and methods: Sixteen patients with advanced H&N tumours were enrolled. Cervical-SCS devices were inserted subcutaneously prior to commencement of scheduled chemoradiotherapy. Pre- and post-SCS measurements were as follows: (i) tumour oxygenation (mmHg) using polarographic probes; (ii) blood flow quantification (ml/min) and diastolic and systolic velocimetry (cm/s) in the CCA using colour Doppler. Results: After SCS, median tumour oxygenation increased in two-thirds of patients (34%; P = 0.023), all patients had improved CCA blood flow (50%; P <0.001) and almost all patients showed an increased CCA diastolic velocity (26%; P = 0.003) and systolic velocity (20%; P = 0.011). Conclusions: Cervical-SCS increased tumour oxygenation and CCA blood flow, and could enhance the loco-regional delivery of oxygen, radiosensitising and chemotherapeutic drugs. Cervical-SCS as adjuvant in chemoradiotherapy of these tumours warrants further investigation.
URI: http://hdl.handle.net/10553/47744
ISSN: 0923-7534
DOI: 10.1093/annonc/mdh189
Source: Annals of Oncology[ISSN 0923-7534],v. 15(5), p. 802-807
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

25
checked on Jun 26, 2022

Page view(s)

14
checked on May 21, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.