Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47744
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dc.contributor.authorClavo, Bernardinoen_US
dc.contributor.authorRobaina, F.en_US
dc.contributor.authorCatalá, L.en_US
dc.contributor.authorPérez, J. L.en_US
dc.contributor.authorLloret, M.en_US
dc.contributor.authorCaramés, M. Áen_US
dc.contributor.authorMorera, J.en_US
dc.contributor.authorLópez, L.en_US
dc.contributor.authorSuárez, G.en_US
dc.contributor.authorMacías, D.en_US
dc.contributor.authorRivero, J.en_US
dc.contributor.authorHernández, M. A.en_US
dc.date.accessioned2018-11-23T16:03:01Z-
dc.date.available2018-11-23T16:03:01Z-
dc.date.issued2004en_US
dc.identifier.issn0923-7534en_US
dc.identifier.urihttp://hdl.handle.net/10553/47744-
dc.description.abstractBackground: Tumour ischaemia leads to decreased delivery of oxygen, chemotherapy and radiosensitisers. Hypoxia in head and neck (H&N) tumours is an important adverse prognostic factor. Spinal cord stimulation (SCS) is a well-established neurosurgical technique in the treatment of several ischaemic syndromes. This prospective study evaluated the effect of cervical-SCS on common carotid artery (CCA) blood flow and tumour oxygenation in patients with advanced H&N cancer. Patients and methods: Sixteen patients with advanced H&N tumours were enrolled. Cervical-SCS devices were inserted subcutaneously prior to commencement of scheduled chemoradiotherapy. Pre- and post-SCS measurements were as follows: (i) tumour oxygenation (mmHg) using polarographic probes; (ii) blood flow quantification (ml/min) and diastolic and systolic velocimetry (cm/s) in the CCA using colour Doppler. Results: After SCS, median tumour oxygenation increased in two-thirds of patients (34%; P = 0.023), all patients had improved CCA blood flow (50%; P <0.001) and almost all patients showed an increased CCA diastolic velocity (26%; P = 0.003) and systolic velocity (20%; P = 0.011). Conclusions: Cervical-SCS increased tumour oxygenation and CCA blood flow, and could enhance the loco-regional delivery of oxygen, radiosensitising and chemotherapeutic drugs. Cervical-SCS as adjuvant in chemoradiotherapy of these tumours warrants further investigation.en_US
dc.languageengen_US
dc.relation.ispartofAnnals of Oncologyen_US
dc.sourceAnnals of Oncology[ISSN 0923-7534],v. 15(5), p. 802-807en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject.otherBlood flowen_US
dc.subject.otherColour Doppleren_US
dc.subject.otherHead & neck canceren_US
dc.subject.otherSpinal cord stimulationen_US
dc.subject.otherTranscranial Doppleren_US
dc.subject.otherTumour oxygenationen_US
dc.titleEffect of cervical spinal cord stimulation on regional blood flow and oxygenation in advanced head and neck tumoursen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/annonc/mdh189en_US
dc.identifier.scopus2642521439-
dc.contributor.authorscopusid57190093030-
dc.contributor.authorscopusid6603449723-
dc.contributor.authorscopusid6701325136-
dc.contributor.authorscopusid7403417565-
dc.contributor.authorscopusid7003855087-
dc.contributor.authorscopusid6505906726-
dc.contributor.authorscopusid35466252100-
dc.contributor.authorscopusid56243678000-
dc.contributor.authorscopusid7101855600-
dc.contributor.authorscopusid35582506700-
dc.contributor.authorscopusid7006478796-
dc.contributor.authorscopusid8616779200-
dc.description.lastpage807en_US
dc.description.firstpage802en_US
dc.relation.volume15en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2004en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr4,335-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.orcid0000-0003-2522-1064-
crisitem.author.fullNameClavo Varas, Bernardino-
crisitem.author.fullNameCaramés Álvarez, Miguel Angel-
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