Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47720
Title: Autologous platelet-poor plasma decreases the bronchial stump necrosis in rat
Authors: Santana-Rodríguez, Norberto
Llontop, Pedro
Clavo, Bernardino 
Camacho, Rafael
Quintana, Ardiel
Fiuza, María D.
García-Castellano, José Manuel
Ponce-González, Miguel A.
Zerecero, Keila
Fernández-Pérez, Leandro 
Brito-Godoy, Yanira
Ruíz-Caballero, José A.
Keywords: Rich Plasma
Growth-Factors
Fibrin Glue
Issue Date: 2013
Publisher: 0022-4804
Project: Estudio Funcional y Molecular de Las Proteínas Socs en Un Modelo de Resistencia Hepática A Insulina. 
Journal: Journal of Surgical Research 
Abstract: Background: Necrosis of the bronchial stump is a very important trigger for bronchopleural fistula. The administration of local autologous platelet-poor plasma (PPP) could protect the bronchial stump.Materials and methods: Left pneumonectomy was performed in 25 Sprague-Dawley rats. Animals were randomly assigned to a control group (n = 13) and PPP group (n = 12). PPP was locally administered on the bronchial stump after pneumonectomy. We analyzed histologic changes in the bronchial stump and messenger RNA expression changes of genes involved in wound repair at 10 and 20 d.Results: Local PPP treatment produced a mass of fibrous tissue surrounding the bronchial stump and significantly decreased the presence of necrosis at 20 d. PPP increased the expression of insulin like growth factor 1 at 10 d although it did not reach statistical significance.Conclusions: Our findings indicate that local PPP treatment of the bronchial stump after pneumonectomy decreased necrosis and could have a protective effect on the bronchial stump. (C) 2013 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10553/47720
ISSN: 0022-4804
DOI: 10.1016/j.jss.2012.12.039
Source: Journal of Surgical Research[ISSN 0022-4804],v. 183, p. 68-74
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