Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47517
Title: Complex polysaccharide inclusions in the skeletal muscle of stranded cetaceans
Authors: Sierra Pulpillo, Eva María 
Fernández Rodríguez, Antonio Jesús 
Espinosa De Los Monteros Y Zayas, Antonio 
Jáber Mohamad, José Raduán 
Andrada Borzollino, Marisa Ana 
Herráez Thomas, Pedro Manuel 
UNESCO Clasification: 240110 Histología animal
240118 Mamíferos
Keywords: Glycogen-Storage-Disease
Exertional Rhabdomyolysis
Myopathy
Mutation
Necropsy, et al
Issue Date: 2012
Publisher: 1090-0233
Journal: Veterinary Journal 
Abstract: Skeletal muscle samples were examined post-mortem in 148 cetaceans over a 12-year period. Histological analysis included haematoxylin and eosin (HE) and periodic acid-Schiff (PAS) staining with and without diastase digestion. In addition, histological muscle sections were immunostained for ubiquitin and fast and slow heavy-chain myosin isoforms.PAS-positive, diastase-resistant inclusions were detected in 26 animals from 11 different species. Older cetaceans were preferentially affected. These intrafibre inclusions varied from large aggregates to multiple coarse granules and were typically associated with type II fibres. All diastase-resistant inclusions were positive for ubiquitin. These features resembled those inclusions described as complex polysaccharide in horses. Based on these histological findings and the ubiquitin staining pattern, a morphological diagnosis of complex polysaccharide storage myopathy is proposed.
URI: http://hdl.handle.net/10553/47517
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2011.09.021
Source: The Veterinary Journal [ISSN 1090-0233], v. 193 (1), p. 152-156
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