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http://hdl.handle.net/10553/47397
Title: | Long-term valuation of oral mavacoxib in osteoarthrosic dogs using force platform analysis | Authors: | Vilar Guereño, José Manuel Morales Doreste, Manuel Francisco Santana Del Pino, Ángelo Batista Arteaga, Miguel Miró Rodríguez, Francisco Spinella, Giuseppe |
UNESCO Clasification: | 240111 Patología animal 310907 Patología |
Keywords: | Dog Force platform Lameness Mavacoxib Osteoarthrosis, et al |
Issue Date: | 2013 | Publisher: | 0253-8318 | Journal: | Pakistan Veterinary Journal | Abstract: | The aim of this study was to assess the efficacy of mavacoxib, a cox-2 inhibitor, to improve the peak vertical force (PVF) and vertical impulse (VI) of lame client-owned dogs with severe coxofemoral osteoarthrosis (OA) by using a force platform. A group of ten canarian presa dogs with lameness and pain for a severe osteoarthrosis due to hip dysplasia were used for this study. Five additional sound dogs of the same breed were used as control groups. A single force platform used to register vertical forces was mounted in a 7 m runway. Mean (+/- SD) values for speed of dogs were 1.6 +/- 0.5 m/s. Data corresponding with 5 valid trials were recorded at walk at day 0, 7, 60 and 180 after starting treatment procedure. The dosing regimen consisted of a loading oral dose of 2 mg/kg to be repeated after 14 days, thereafter the dosing interval was 1 month. OA dogs showed a significant improvement of PVF after two months of about 7% bm in the force exerted by diseased limbs and a significant VI improvement after two months of about 1.6% bm in the VI exerted by diseased limbs. This study clearly showed that dogs treated with mavacoxib increased PVF over time, as soon as seven days after medical therapy, demonstrating a high potential for clinical use in the treatment of lameness associated with OA of hip joint. | URI: | http://hdl.handle.net/10553/47397 | ISSN: | 0253-8318 | Source: | Pakistan Veterinary Journal [ISSN 0253-8318], v. 33 (2), p. 229-233 |
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