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Title: Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis
Authors: Vilar Guereño, José Manuel 
Batista Arteaga, Miguel 
Morales Doreste, Manuel Francisco 
Santana Del Pino, Ángelo 
Cuervo Serrato, Belén
Rubio Zaragoza, Mónica
Cugat Bertomeu, Ramón
Sopena Juncosa, Joaquín
Carrillo Poveda, José María
UNESCO Clasification: 240111 Patología animal
310907 Patología
Keywords: Osteoarthrosis
Adipose-derived mesenchymal stem cells
Force platform, et al
Issue Date: 2014
Journal: BMC Veterinary Research 
Abstract: Background Regenerative medicine using Mesenchymal Stem Cells (MSC) alone or combined with Plasma Rich in Growth Factors (PRGF) is a rapidly growing area of clinical research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify and quantify the efficacy of different therapeutic strategies for the treatment of OA in dogs including MSC associated to PRGF, but never with AD-MSC alone. The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA. Results Ten lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved within the first three months post-treatment in the OA group, increasing 9% and 2.5% body weight, respectively, at day 30. After this, the effect seems to decrease reaching initial values. Conclusion Intraarticular ADMSC therapy objectively improved limb function in dogs with hip OA. The duration of maximal effect was less than 3 months.
ISSN: 1746-6148
DOI: 10.1186/1746-6148-10-143
Source: BMC Veterinary Research [ISSN 1746-6148], v. 10 (1), 143
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