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Title: Mindfulness in the maintenance of cognitive capacities in Alzheimer's disease: a randomized clinical trial
Authors: Quintana-Hernández, Domingo J.
Miró-Barrachina, Maria T.
Ibáñez-Fernández, Ignacio J.
Santana-Del Pino, Angelo 
Quintana-Montesdeoca, Maria P.
Rodríguez-De Vera, Bienvenida 
Morales-Casanova, David
Del Carmen Pérez-Vieitez, Maria
Rodríguez-García, Javier
Bravo-Caraduje, Noelia
UNESCO Clasification: 32 Ciencias médicas
240401 Bioestadística
120903 Análisis de datos
Keywords: Progressive Muscle-Relaxation
Default-Mode Network
Stimulation Therapy
Stress Reduction
Older-Adults, et al
Issue Date: 2015
Journal: Journal of Alzheimer's Disease 
Abstract: Background: The Canary Islands longitudinal study on non-pharmacological treatments showed the overall effectiveness of mindfulness in Alzheimer's disease (AD). However, no specific data on the maintenance of cognitive capacities were presented.Objective: To determine whether the practice of mindfulness modifies the course of cognitive impairment in AD.Methods: Design: Longitudinal, non-inferiority and equivalence, randomized clinical trial, repeated-measures design, with three experimental groups and one control group. Participants: Patients with AD who voluntarily attended the Lidia Garcia Foundation (n = 502). Only those who were treated with donepezil and MMSE >= 18 were included (n = 120). Intervention: Over a two-year period, each group carried out three weekly sessions of stimulation based on mindfulness, cognitive stimulation therapy, and progressive muscle relaxation. Measures: Cognitive assessment CAMDEX-R (MMSE and CAMCOG). Statistical analysis: Repeated-measures ANOVA (p < 0.05) and the effect size Cohen's d were performed.Results: The mindfulness group showed significant scores compared with the control and muscle relaxation groups (p < 0.05), while mindfulness and cognitive stimulation therapy were equivalent (p >= 0.05). Group cognitive stimulation evolved better than the control (p < 0.05) group but not better than the muscle relaxation group (p >= 0.05). The effect size compared over two years was large for the mindfulness group (p >= 0.80), moderate for the relaxation group (p >= 0.50), and low for the cognitive stimulation group (p >= 0.20).Conclusion: The practice of mindfulness maintained cognitive function over a period of two years. This longitudinal study suggests that mindfulness can be used as a non-pharmacological treatment to slow cognitive impairment in AD.
ISSN: 1387-2877
DOI: 10.3233/JAD-143009
Source: Journal of Alzheimer's Disease [ISSN 1387-2877], v. 50, p. 217-232
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