Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47390
Title: Mindfulness in the maintenance of cognitive capacities in Alzheimer's disease: a randomized clinical trial
Authors: Quintana-Hernández, Domingo J.
Miró-Barrachina, Maria T.
Ibáñez-Fernández, Ignacio J.
Santana-Del Pino, Angelo 
Quintana-Montesdeoca, Maria P.
Rodríguez-De Vera, Bienvenida 
Morales-Casanova, David
Del Carmen Pérez-Vieitez, Maria
Rodríguez-García, Javier
Bravo-Caraduje, Noelia
UNESCO Clasification: 32 Ciencias médicas
240401 Bioestadística
120903 Análisis de datos
Keywords: Progressive Muscle-Relaxation
Default-Mode Network
Stimulation Therapy
Stress Reduction
Older-Adults, et al
Issue Date: 2015
Journal: Journal of Alzheimer's Disease 
Abstract: Background: The Canary Islands longitudinal study on non-pharmacological treatments showed the overall effectiveness of mindfulness in Alzheimer's disease (AD). However, no specific data on the maintenance of cognitive capacities were presented.Objective: To determine whether the practice of mindfulness modifies the course of cognitive impairment in AD.Methods: Design: Longitudinal, non-inferiority and equivalence, randomized clinical trial, repeated-measures design, with three experimental groups and one control group. Participants: Patients with AD who voluntarily attended the Lidia Garcia Foundation (n = 502). Only those who were treated with donepezil and MMSE >= 18 were included (n = 120). Intervention: Over a two-year period, each group carried out three weekly sessions of stimulation based on mindfulness, cognitive stimulation therapy, and progressive muscle relaxation. Measures: Cognitive assessment CAMDEX-R (MMSE and CAMCOG). Statistical analysis: Repeated-measures ANOVA (p < 0.05) and the effect size Cohen's d were performed.Results: The mindfulness group showed significant scores compared with the control and muscle relaxation groups (p < 0.05), while mindfulness and cognitive stimulation therapy were equivalent (p >= 0.05). Group cognitive stimulation evolved better than the control (p < 0.05) group but not better than the muscle relaxation group (p >= 0.05). The effect size compared over two years was large for the mindfulness group (p >= 0.80), moderate for the relaxation group (p >= 0.50), and low for the cognitive stimulation group (p >= 0.20).Conclusion: The practice of mindfulness maintained cognitive function over a period of two years. This longitudinal study suggests that mindfulness can be used as a non-pharmacological treatment to slow cognitive impairment in AD.
URI: http://hdl.handle.net/10553/47390
ISSN: 1387-2877
DOI: 10.3233/JAD-143009
Source: Journal of Alzheimer's Disease [ISSN 1387-2877], v. 50, p. 217-232
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

28
checked on Jul 25, 2021

WEB OF SCIENCETM
Citations

20
checked on May 9, 2021

Page view(s)

56
checked on Jul 31, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.