Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47359
Title: Arterial to end‐tidal Pco2 difference during exercise in normoxia and severe acute hypoxia: importance of blood temperature correction
Authors: Losa-Reyna, José
Torres-Peralta, Rafael 
González Henriquez, Juan José 
Calbet, José A.L. 
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Blood temperature
Gas exchange
Gradient
Hypoxia
PCO2
Issue Date: 2015
Journal: Physiological Reports 
Abstract: Negative arterial to end-tidal PCO2 differences ((a-ET)PCO2) have been reported in normoxia. To determine the influence of blood temperature on (a-ET)PCO2, 11 volunteers (21 ± 2 years) performed incremental exercise to exhaustion in normoxia (Nx, PIO2: 143 mmHg) and hypoxia (Hyp, PIO2: 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with end-tidal PCO2 (PETCO2). After accounting for blood temperature, the (a-ET) PCO2 was reduced (in absolute values) from -4.2 ± 1.6 to -1.1 ± 1.5 mmHg in normoxia and from -1.7 ± 1.6 to 0.9 ± 0.9 mmHg in hypoxia (both P < 0.05). The temperature corrected (a-ET)PCO2 was linearly related with absolute and relative exercise intensity, VO2, VCO2, and respiratory rate (RR) in normoxia and hypoxia (R2: 0.52- 0.59). Exercise CO2 production and PETCO2 values were lower in hypoxia than normoxia, likely explaining the greater (less negative) (a-ET)PCO2 difference in hypoxia than normoxia (P < 0.05). At near-maximal exercise intensity the (a-ET)PCO2 lies close to 0 mmHg, that is, the mean PaCO2 and the mean PETCO2 are similar. The mean exercise (a-ET)PCO2 difference is closely related to the mean A-aDO2 difference (r = 0.90, P < 0.001), as would be expected if similar mechanisms perturb the gas exchange of O2 and CO2 during exercise. In summary, most of the negative (a-ET)PCO2 values observed in previous studies are due to lack of correction of PaCO2 for blood temperature. The absolute magnitude of the (a-ET)PCO2 difference is lower during exercise in hypoxia than normoxia.
URI: http://hdl.handle.net/10553/47359
ISSN: 2051-817X
DOI: 10.14814/phy2.12512
Source: Physiological Reports, [ISSN: 2051-817X] v. 3 (10). e12512
Appears in Collections:Artículos
Thumbnail
pdf
Adobe PDF (201,76 kB)
Show full item record

SCOPUSTM   
Citations

13
checked on Aug 1, 2021

WEB OF SCIENCETM
Citations

12
checked on Aug 1, 2021

Page view(s)

43
checked on Jul 31, 2021

Download(s)

38
checked on Jul 31, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.