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Title: Quantitative analysis of p185(HER-2/neu) protein in breast cancer and its association with other prognostic factors
Authors: Valerón, Pilar F. 
Chirino, Ricardo 
Vega Benítez, Víctor Manuel 
Falcón, Orlando
Rivero, Juan F.
Torres Curbelo, Santiago 
León Arencibia, Laureano 
Fernández, Leandro 
Pestano, J 
Díaz-Chico, Bonifacio 
DiazChico, JC 
UNESCO Clasification: 32 Ciencias médicas
320101 Oncología
Keywords: Cathepsin-D Expression
Her-2/Neu Amplification
Assay, et al
Issue Date: 1997
Journal: International Journal of Cancer 
Abstract: The total cellular p185(HER-2/neu) protein (p185) content was measured by ELISA in 346 invasive primary breast cancers, and the results were compared with those of estrogen (ER) and progesterone (PR) receptors, pS2 and Cathepsin D (Cat D) content. At a cut-off level of 260 fmol/mg protein, 53 of the 346 tumors (15%) were p185 positive. A significant positive correlation was observed between p185 levels and those of Cat D, and a weaker, though significant, positive correlation with ER, and pS2 levels, but not with those of PR. However, when only the 293 p185-negative tumors were considered, the correlation between p185 and ER improved substantially, and statistical significance was reached for PR. p185-positive tumors exhibited lower ER and PR content and higher Cat D content than p185-negative tumors. The pS2 content, in contrast, did not undergo significant variation, Tumors considered to be p185-positive were significantly more frequently positive for Cat D at the cut-off of 45 pmol/mg protein, and were more frequently negative for ER and/or PR, but only significant at the cut-off of 15 fmol/mg or higher for both steroid receptors. Finally, p185 status was not associated with menopausal status, tumor size, axillary-lymph-node invasiveness or distant metastases. These results suggest that 260 fmol/mg protein as the cut-off for p185 allows the identification of a tumoral sub-population with a more aggresive phenotype.
ISSN: 0020-7136
DOI: 10.1002/(SICI)1097-0215(19970422)74:2<175::AID-IJC6>3.0.CO;2-W
Source: International Journal Of Cancer[ISSN 0020-7136],v. 74 (2), p. 175-179
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