|Title:||Quantitative analysis of p185(HER-2/neu) protein in breast cancer and its association with other prognostic factors||Authors:||Valerón, Pilar F.
Vega Benítez, Víctor Manuel
Rivero, Juan F.
Torres Curbelo, Santiago
León Arencibia, Laureano
|UNESCO Clasification:||32 Ciencias médicas
Assay, et al
|Issue Date:||1997||Journal:||International Journal of Cancer||Abstract:||The total cellular p185(HER-2/neu) protein (p185) content was measured by ELISA in 346 invasive primary breast cancers, and the results were compared with those of estrogen (ER) and progesterone (PR) receptors, pS2 and Cathepsin D (Cat D) content. At a cut-off level of 260 fmol/mg protein, 53 of the 346 tumors (15%) were p185 positive. A significant positive correlation was observed between p185 levels and those of Cat D, and a weaker, though significant, positive correlation with ER, and pS2 levels, but not with those of PR. However, when only the 293 p185-negative tumors were considered, the correlation between p185 and ER improved substantially, and statistical significance was reached for PR. p185-positive tumors exhibited lower ER and PR content and higher Cat D content than p185-negative tumors. The pS2 content, in contrast, did not undergo significant variation, Tumors considered to be p185-positive were significantly more frequently positive for Cat D at the cut-off of 45 pmol/mg protein, and were more frequently negative for ER and/or PR, but only significant at the cut-off of 15 fmol/mg or higher for both steroid receptors. Finally, p185 status was not associated with menopausal status, tumor size, axillary-lymph-node invasiveness or distant metastases. These results suggest that 260 fmol/mg protein as the cut-off for p185 allows the identification of a tumoral sub-population with a more aggresive phenotype.||URI:||http://hdl.handle.net/10553/47001||ISSN:||0020-7136||DOI:||10.1002/(SICI)1097-0215(19970422)74:2<175::AID-IJC6>3.0.CO;2-W||Source:||International Journal Of Cancer[ISSN 0020-7136],v. 74 (2), p. 175-179|
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