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Title: IL4-R1 (5q31-q33) and Fc epsilon RI-beta ca (11q13) markers and atopy: a case/control study in a Spanish population
Authors: Torres-Galván, M.
Quiralte, J.
Pestano, J. J. 
Ortega, N.
Blanco, C.
Castillo, R.
Carrillo, T. 
Pérez-Aciego, P.
Sánchez-García, F.
Keywords: Serum Ige Levels
Linkage Analysis
Chromosome 5Q31
Canary-Islands, et al
Issue Date: 2001
Publisher: 0105-4538
Journal: Allergy: European Journal of Allergy and Clinical Immunology 
Abstract: Background: Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4-R1 (chromosome 5q31-q33) and Fc epsilon RI-beta ca (chromosome 11q13) markers with the atopic disease in our population.Methods: We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4-R1 and Fc epsilon RI-beta ca microsatellites was carried out by PCR and electrophoresis in acrylamide gels.Results: We have not found evidence of association between IL4-R1 and Fc epsilon RI-beta ca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis.Conclusions: IL4-R1 and Fc epsilon RI-beta ca markers have not proved to be useful genetic markers for linkage or association studies in our population.
ISSN: 0105-4538
DOI: 10.1034/j.1398-9995.2001.056002159.x
Source: Allergy: European Journal of Allergy and Clinical Immunology[ISSN 0105-4538],v. 56(2), p. 159-163, (Febrero 2001)
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