Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46995
Title: IL4-R1 (5q31-q33) and Fc epsilon RI-beta ca (11q13) markers and atopy: a case/control study in a Spanish population
Authors: Torres-Galván, M.
Quiralte, J.
Pestano, J. J. 
Ortega, N.
Blanco, C.
Castillo, R.
Carrillo, T. 
Pérez-Aciego, P.
Sánchez-García, F.
Keywords: Serum Ige Levels
Immunoglobulin-E
Linkage Analysis
Chromosome 5Q31
Canary-Islands, et al
Issue Date: 2001
Publisher: 0105-4538
Journal: Allergy: European Journal of Allergy and Clinical Immunology 
Abstract: Background: Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4-R1 (chromosome 5q31-q33) and Fc epsilon RI-beta ca (chromosome 11q13) markers with the atopic disease in our population.Methods: We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4-R1 and Fc epsilon RI-beta ca microsatellites was carried out by PCR and electrophoresis in acrylamide gels.Results: We have not found evidence of association between IL4-R1 and Fc epsilon RI-beta ca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis.Conclusions: IL4-R1 and Fc epsilon RI-beta ca markers have not proved to be useful genetic markers for linkage or association studies in our population.
URI: http://hdl.handle.net/10553/46995
ISSN: 0105-4538
DOI: 10.1034/j.1398-9995.2001.056002159.x
Source: Allergy: European Journal of Allergy and Clinical Immunology[ISSN 0105-4538],v. 56(2), p. 159-163, (Febrero 2001)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

8
checked on Jul 25, 2021

WEB OF SCIENCETM
Citations

7
checked on Jul 25, 2021

Page view(s)

26
checked on Jul 17, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.