Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46791
Title: Non-albuminuric renal disease among subjects with advanced stages of chronic kidney failure related to type 2 diabetes mellitus
Authors: Boronat, Mauro 
García-Cantón, César 
Quevedo, Virginia
Lorenzo, Dionisio L. 
López-Ríos, Laura
Batista, Fátima
Riaño, Marta
Saavedra, Pedro
Checa, María D.
Keywords: Risk-Factors
Serum Creatinine
Nephropathy
Population
Insufficiency
Retinopathy
Impairment
Prediction
Neuropathy
Niddm
Issue Date: 2014
Publisher: 0886-022X
Journal: Renal Failure 
Abstract: Urinary albumin excretion has been consistently found to be normal in a significant number of subjects with early stages of diabetic kidney disease. This study was aimed to estimate the prevalence and characteristics of non-albuminuric chronic kidney disease associated with type 2 diabetes mellitus among subjects who reach advanced stages of renal failure. Study population was composed of incident patients with advanced chronic kidney disease (glomerular filtration rate <30 mL/min) related to type 2 diabetes in a tertiary hospital from Gran Canaria (Spain) during a period of 2 years. Subjects were classified as normoalbuminuric (urinary albumin-to-creatine ratio [UACR] <30 mg/g), microalbuminuric (UACR >= 30 and 5300 mg/g), or proteinuric (UACR >= 300 mg/g). Of 78 eligible patients, 21.8% had normoalbuminuria, 20.5% had microalbuminuria, and 57.7% had proteinuria. Individuals with normoalbuminuria were mostly women and had a lower prevalence of smoking and polyneuropathy than subjects with microalbuminuria or proteinuria. They also presented greater measures of body mass index and waist circumference, higher values of total and LDL cholesterol, and lower values of HbA(1c) and serum creatinine than subjects with microalbuminuria or proteinuria. Multivariate analysis demonstrated that female sex (positively) and HbA(1c) and polyneuropathy (negatively) were independently associated with absence of albuminuria. In conclusion, around 20% of subjects with diabetes-related advanced chronic kidney disease, characteristically women, have normal urinary albumin excretion. HbA(1c) and polyneuropathy are inversely related to this non-albuminuric form of nephropathy.
URI: http://hdl.handle.net/10553/46791
ISSN: 0886-022X
DOI: 10.3109/0886022X.2013.835266
Source: Renal Failure[ISSN 0886-022X],v. 36, p. 166-170
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