Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46112
Campo DC Valoridioma
dc.contributor.authorGuha, Chandanen_US
dc.contributor.authorYamanouchi, Koshoen_US
dc.contributor.authorJiang, Jinlanen_US
dc.contributor.authorWang, Xiaen_US
dc.contributor.authorChowdhury, Namita Royen_US
dc.contributor.authorSantana, Alfredoen_US
dc.contributor.authorShapiro, Lawrence J.en_US
dc.contributor.authorSalido, Eduardoen_US
dc.contributor.authorRoy-Chowdhury, Jayantaen_US
dc.date.accessioned2018-11-23T01:28:51Z-
dc.date.available2018-11-23T01:28:51Z-
dc.date.issued2005en_US
dc.identifier.issn0250-8095en_US
dc.identifier.urihttp://hdl.handle.net/10553/46112-
dc.description.abstractPrimary hyperoxalurias (PHs) are diseases caused by overproduction of oxalate by hepatocytes. Most patients with PHs develop nephrocalcinosis and renal failure. Combined liver-kidney transplantation is often used as a definitive treatment of PHs, but because of a large body oxalate load at the time of transplantation, the procedure is not always successful. Because all hepatocytes overproduce oxalate, partial liver replacement procedures, such as auxiliary transplantation of a liver lobe or hepatocyte transplantation are not expected to be useful in this disorder. In this paper we describe novel techniques, based on preparative hepatic irradiation and stimulation of hepatocyte mitosis, through loss of liver mass or administration of hepatic growth factor, which permit transplanted wild-type hepatocytes to massively repopulate the liver, replacing up to 90% of the hepatocytes in recipient mouse livers. Application of this procedure in a recently developed Agxt-gene-deleted mouse model of PH1 resulted in marked amelioration of hyperoxaluria. We propose that further refinement of the different components of this procedure may permit early cell-based therapies of PHs, thereby preventing renal failure and its complications.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Nephrologyen_US
dc.sourceAmerican Journal of Nephrology [ISSN 0250-8095],v. 25, p. 161-170en_US
dc.subject32 Ciencias médicasen_US
dc.subject320506 Nefrologíaen_US
dc.subject.otherHepatocyte transplantationen_US
dc.subject.otherPrimary hyperoxaluriasen_US
dc.subject.otherHepatic irradiationen_US
dc.subject.otherFas/CD95en_US
dc.subject.otherHepatic growth factoren_US
dc.titleFeasibility of hepatocyte transplantation-based therapies for primary hyperoxaluriasen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.typeConferenceObjecten_US
dc.identifier.doi10.1159/000085408en_US
dc.identifier.scopus20844442634-
dc.contributor.authorscopusid7003685546-
dc.contributor.authorscopusid18234451800-
dc.contributor.authorscopusid56134148500-
dc.contributor.authorscopusid55413994800-
dc.contributor.authorscopusid35494008000-
dc.contributor.authorscopusid55617275900-
dc.contributor.authorscopusid7402091340-
dc.contributor.authorscopusid14023538500-
dc.contributor.authorscopusid35482731200-
dc.description.lastpage170en_US
dc.description.firstpage161en_US
dc.relation.volume25en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Actas de congresosen_US
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.date.coverdateMarzo-abrilen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,459
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid000-0002-1075-9948-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSantana Rodríguez, Alfredo-
Colección:Actas de congresos
Vista resumida

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.