Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46112
Título: Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias
Autores/as: Guha, Chandan
Yamanouchi, Kosho
Jiang, Jinlan
Wang, Xia
Chowdhury, Namita Roy
Santana, Alfredo 
Shapiro, Lawrence J.
Salido, Eduardo
Roy-Chowdhury, Jayanta
Clasificación UNESCO: 32 Ciencias médicas
320506 Nefrología
Palabras clave: Hepatocyte transplantation
Primary hyperoxalurias
Hepatic irradiation
Fas/CD95
Hepatic growth factor
Fecha de publicación: 2005
Publicación seriada: American Journal of Nephrology 
Resumen: Primary hyperoxalurias (PHs) are diseases caused by overproduction of oxalate by hepatocytes. Most patients with PHs develop nephrocalcinosis and renal failure. Combined liver-kidney transplantation is often used as a definitive treatment of PHs, but because of a large body oxalate load at the time of transplantation, the procedure is not always successful. Because all hepatocytes overproduce oxalate, partial liver replacement procedures, such as auxiliary transplantation of a liver lobe or hepatocyte transplantation are not expected to be useful in this disorder. In this paper we describe novel techniques, based on preparative hepatic irradiation and stimulation of hepatocyte mitosis, through loss of liver mass or administration of hepatic growth factor, which permit transplanted wild-type hepatocytes to massively repopulate the liver, replacing up to 90% of the hepatocytes in recipient mouse livers. Application of this procedure in a recently developed Agxt-gene-deleted mouse model of PH1 resulted in marked amelioration of hyperoxaluria. We propose that further refinement of the different components of this procedure may permit early cell-based therapies of PHs, thereby preventing renal failure and its complications.
URI: http://hdl.handle.net/10553/46112
ISSN: 0250-8095
DOI: 10.1159/000085408
Fuente: American Journal of Nephrology [ISSN 0250-8095],v. 25, p. 161-170
Colección:Actas de congresos
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