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Title: Immunoprotective effect of cysteine proteinase fractions from two Haemonchus contortus strains adapted to sheep and goats
Authors: Molina Caballero, José Manuel 
Martín, S. 
Hernández, Y. I.
González, J. F. 
Ferrer, O. 
Ruiz Reyes, Antonio 
Keywords: Protective Antigen
Proteases, et al
Issue Date: 2012
Publisher: 0304-4017
Journal: Veterinary Parasitology 
Abstract: A preliminary analysis of the significance of genetic diversity in cysteine proteinase genes has been performed simultaneously in sheep and goats, with regard to the immunological control using these enzymes against haemonchosis. For this purpose, we have studied the cross-immunoprotective effect of cysteine protease-enriched protein fractions (CPFs) in adult worms of two Haemonchus contortus strains from North America and Spain that are adapted to sheep and goats, respectively. Previous genetic analysis of cysteine proteinase genes in both strains has shown that some of loci are polymorphic and these differences are translated into changes in the amino acid sequences. However, our results show that CPFs from H. contortus adult worms have a protective effect against the parasite in both sheep and goats. These results are similar regardless of whether they were obtained from sheep or goat-adapted H. contortus strains, which could be very important in case H. contortus CPFs were commercially used in different countries, as vaccines to prevent the negative effects of this parasite.Interestingly, this experimental inoculation of both species with a heterologous strain of H. contortus contributes to the idea shown in previous studies about how difficult is the interpretation and the comparison of vaccination where strains not adapted to a specific host are used. Therefore, the challenger of using heterologous strains could provide similar results to those observed in immunised animals. This study suggests the possibility of exploring the mechanisms involved in natural protection against non-adapted strains, in order to develop strategies to control haemonchosis. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2012.03.010
Source: Veterinary Parasitology[ISSN 0304-4017],v. 188, p. 53-59
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