Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45919
DC FieldValueLanguage
dc.contributor.authorMolina Caballero, José Manuelen_US
dc.contributor.authorMartín, S.en_US
dc.contributor.authorHernández, Y. I.en_US
dc.contributor.authorGonzález, J. F.en_US
dc.contributor.authorFerrer, O.en_US
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.date.accessioned2018-11-22T13:38:46Z-
dc.date.available2018-11-22T13:38:46Z-
dc.date.issued2012en_US
dc.identifier.issn0304-4017en_US
dc.identifier.urihttp://hdl.handle.net/10553/45919-
dc.description.abstractA preliminary analysis of the significance of genetic diversity in cysteine proteinase genes has been performed simultaneously in sheep and goats, with regard to the immunological control using these enzymes against haemonchosis. For this purpose, we have studied the cross-immunoprotective effect of cysteine protease-enriched protein fractions (CPFs) in adult worms of two Haemonchus contortus strains from North America and Spain that are adapted to sheep and goats, respectively. Previous genetic analysis of cysteine proteinase genes in both strains has shown that some of loci are polymorphic and these differences are translated into changes in the amino acid sequences. However, our results show that CPFs from H. contortus adult worms have a protective effect against the parasite in both sheep and goats. These results are similar regardless of whether they were obtained from sheep or goat-adapted H. contortus strains, which could be very important in case H. contortus CPFs were commercially used in different countries, as vaccines to prevent the negative effects of this parasite.Interestingly, this experimental inoculation of both species with a heterologous strain of H. contortus contributes to the idea shown in previous studies about how difficult is the interpretation and the comparison of vaccination where strains not adapted to a specific host are used. Therefore, the challenger of using heterologous strains could provide similar results to those observed in immunised animals. This study suggests the possibility of exploring the mechanisms involved in natural protection against non-adapted strains, in order to develop strategies to control haemonchosis. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.languagespaen_US
dc.publisher0304-4017
dc.relation.ispartofVeterinary Parasitologyen_US
dc.sourceVeterinary Parasitology[ISSN 0304-4017],v. 188, p. 53-59en_US
dc.subject.otherProtective Antigenen_US
dc.subject.otherExperimental-Infectionen_US
dc.subject.otherGenetic-Variabilityen_US
dc.subject.otherVaccinationen_US
dc.subject.otherProteasesen_US
dc.subject.otherMembraneen_US
dc.subject.otherImmunizationen_US
dc.subject.otherResistanceen_US
dc.subject.otherImmunityen_US
dc.subject.otherExtracten_US
dc.titleImmunoprotective effect of cysteine proteinase fractions from two Haemonchus contortus strains adapted to sheep and goatsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.vetpar.2012.03.010en_US
dc.identifier.scopus84863225061-
dc.identifier.isi000306617800009-
dc.contributor.authorscopusid55731962600-
dc.contributor.authorscopusid55450160500-
dc.contributor.authorscopusid8340114700-
dc.contributor.authorscopusid7404492965-
dc.contributor.authorscopusid7003583407-
dc.contributor.authorscopusid57201387360-
dc.description.lastpage59en_US
dc.description.firstpage53en_US
dc.relation.volume188en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid742292-
dc.contributor.daisngid8076508-
dc.contributor.daisngid3084477-
dc.contributor.daisngid1988579-
dc.contributor.daisngid28182072-
dc.contributor.daisngid1497623-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Molina, JM-
dc.contributor.wosstandardWOS:Martin, S-
dc.contributor.wosstandardWOS:Hernandez, YI-
dc.contributor.wosstandardWOS:Gonzalez, JF-
dc.contributor.wosstandardWOS:Ferrer, O-
dc.contributor.wosstandardWOS:Ruiz, A-
dc.date.coverdateAgosto 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,165
dc.description.jcr2,381
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-8338-2512-
crisitem.author.orcid0000-0002-1757-6634-
crisitem.author.orcid0000-0001-7374-9256-
crisitem.author.orcid0000-0001-9038-042X-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNameMolina Caballero, José Manuel-
crisitem.author.fullNameMartín Martel, Sergio-
crisitem.author.fullNameGonzález Pérez, Jorge Francisco-
crisitem.author.fullNameFerrer Quintana, Otilia Rosa-
crisitem.author.fullNameRuiz Reyes, Antonio-
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