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Title: Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population
Authors: Corella, Dolores
Carrasco, Paula
Fitó, Montserrat
Martínez-González, Miguel Angel
Salas-Salvadó, Jordi
Arós, Fernando
Lapetra, José
Guillén, Marisa
Ortega-Azorín, Carolina
Warnberg, Julia
Fiol, Miquel
Ruiz-Gutierrez, Valentina
Serra-Majem, Lluís 
Alfredo Martínez, J.
Ros, Emilio
Estruch, Ramón
Keywords: Ester Transfer Protein
Food-Frequency Questionnaire
Dietary-Fat Intake, et al
Issue Date: 2010
Publisher: 0022-2275
Journal: Journal of Lipid Research 
Abstract: Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D' = 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.-Corella, D., P. Carrasco, M. Fito, M. A. Martinez-Gonzalez, J. Salas-Salvado, F. Aros, J. Lapetra, M. Guillen, C. Ortega-Azorin, J. Warnberg, M. Fiol, V. Ruiz-Gutierrez, L. Serra-Majem, J. A. Martinez, E. Ros, and R. Estruch. Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population. J. Lipid Res. 2010. 51: 2798-2807.
ISSN: 0022-2275
DOI: 10.1194/jlr.P005199
Source: Journal of Lipid Research[ISSN 0022-2275],v. 51, p. 2798-2807
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