Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44725
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dc.contributor.authorCorella, Dolores
dc.contributor.authorCarrasco, Paula
dc.contributor.authorFitó, Montserrat
dc.contributor.authorMartínez-González, Miguel Angel
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorArós, Fernando
dc.contributor.authorLapetra, José
dc.contributor.authorGuillén, Marisa
dc.contributor.authorOrtega-Azorín, Carolina
dc.contributor.authorWarnberg, Julia
dc.contributor.authorFiol, Miquel
dc.contributor.authorRuiz-Gutierrez, Valentina
dc.contributor.authorSerra-Majem, Lluís
dc.contributor.authorAlfredo Martínez, J.
dc.contributor.authorRos, Emilio
dc.contributor.authorEstruch, Ramón
dc.date.accessioned2018-11-22T02:00:00Z-
dc.date.available2018-11-22T02:00:00Z-
dc.date.issued2010
dc.identifier.issn0022-2275
dc.identifier.urihttp://hdl.handle.net/10553/44725-
dc.description.abstractGenome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D' = 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.-Corella, D., P. Carrasco, M. Fito, M. A. Martinez-Gonzalez, J. Salas-Salvado, F. Aros, J. Lapetra, M. Guillen, C. Ortega-Azorin, J. Warnberg, M. Fiol, V. Ruiz-Gutierrez, L. Serra-Majem, J. A. Martinez, E. Ros, and R. Estruch. Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population. J. Lipid Res. 2010. 51: 2798-2807.
dc.publisher0022-2275
dc.relation.ispartofJournal of Lipid Research
dc.sourceJournal of Lipid Research[ISSN 0022-2275],v. 51, p. 2798-2807
dc.subject.otherEster Transfer Protein
dc.subject.otherHigh-Density-Lipoprotein
dc.subject.otherCoronary-Heart-Disease
dc.subject.otherFood-Frequency Questionnaire
dc.subject.otherDietary-Fat Intake
dc.subject.otherTaqib Polymorphism
dc.subject.otherHdl-Cholesterol
dc.subject.otherLipid-Levels
dc.subject.otherPlasma
dc.subject.otherAssociation
dc.titleGene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1194/jlr.P005199
dc.identifier.scopus77956825620-
dc.identifier.isi000280800200031
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid35739810600
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid57208853460
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid7003357665
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid35499702800
dc.contributor.authorscopusid21835135600
dc.contributor.authorscopusid22636249900
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid7004979765
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid24435958700
dc.contributor.authorscopusid35474202600
dc.contributor.authorscopusid7005989830
dc.description.lastpage2807
dc.description.firstpage2798
dc.relation.volume51
dc.type2Artículoes
dc.contributor.daisngid25404
dc.contributor.daisngid650144
dc.contributor.daisngid74443
dc.contributor.daisngid17754
dc.contributor.daisngid25605
dc.contributor.daisngid106289
dc.contributor.daisngid246378
dc.contributor.daisngid1315629
dc.contributor.daisngid1237216
dc.contributor.daisngid230026
dc.contributor.daisngid78038
dc.contributor.daisngid124737
dc.contributor.daisngid28836
dc.contributor.daisngid14474
dc.contributor.daisngid23007
dc.contributor.daisngid19357
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Carrasco, P
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Guillen, M
dc.contributor.wosstandardWOS:Ortega-Azorin, C
dc.contributor.wosstandardWOS:Warnberg, J
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Ruiz-Gutierrez, V
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Martinez, JA
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Estruch, R
dc.date.coverdateSeptiembre 2010
dc.identifier.ulpgces
dc.description.jcr6,115
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
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