Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/44467
DC Field | Value | Language |
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dc.contributor.author | Ström, Kristoffer | en_US |
dc.contributor.author | Morales-Alamo, David | en_US |
dc.contributor.author | Ottosson, Filip | en_US |
dc.contributor.author | Edlund, Anna | en_US |
dc.contributor.author | Hjort, Line | en_US |
dc.contributor.author | Jörgensen, Sine W. | en_US |
dc.contributor.author | Almgren, Peter | en_US |
dc.contributor.author | Zhou, Yuedan | en_US |
dc.contributor.author | Martin-Rincon, Marcos | en_US |
dc.contributor.author | Ekman, Carl | en_US |
dc.contributor.author | Pérez-López, Alberto | en_US |
dc.contributor.author | Ekström, Ola | en_US |
dc.contributor.author | Perez-Suarez, Ismael | en_US |
dc.contributor.author | Mattiasson, Markus | en_US |
dc.contributor.author | De Pablos-Velasco, Pedro | en_US |
dc.contributor.author | Oskolkov, Nikolay | en_US |
dc.contributor.author | Ahlqvist, Emma | en_US |
dc.contributor.author | Wierup, Nils | en_US |
dc.contributor.author | Eliasson, Lena | en_US |
dc.contributor.author | Vaag, Allan | en_US |
dc.contributor.author | Groop, Leif | en_US |
dc.contributor.author | Stenkula, Karin G. | en_US |
dc.contributor.author | Fernandez, Céline | en_US |
dc.contributor.author | Holmberg, Hans Christer | en_US |
dc.contributor.author | Hansson, Ola | en_US |
dc.contributor.author | Calbet, Jose A. | en_US |
dc.date.accessioned | 2018-11-21T23:18:23Z | - |
dc.date.available | 2018-11-21T23:18:23Z | - |
dc.date.issued | 2018 | en_US |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/41846 | - |
dc.description.abstract | Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism. Nicotinamide N-methyltransferase (NNMT) was the most consistently upregulated gene following the energy-deficit exercise. Circulating levels of N-1-methylnicotinamide (MNA), the product of NNMT activity, were doubled after the intervention. The fasting-fed state was an important determinant of plasma MNA levels, peaking at similar to 18 h of fasting and being lowest similar to 3 h after a meal. In culture, MNA was secreted by isolated human myotubes and stimulated lipolysis directly, with no effect on glucagon or insulin secretion. We propose that MNA is a novel myokine that enhances the utilization of energy stores in response to low muscle energy availability. Future research should focus on applying MNA as a biomarker to identify individuals with metabolic disturbances at an early stage. | en_US |
dc.language | eng | en_US |
dc.relation | Viabilidad y Sostenibilidad Del Adelgazamiento Mediante Tratamiento Intensificado en Pacientes Con Sobrepeso U Obesidad: Mecanismos Neuroendocrinos y Moleculares | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.source | Scientific Reports [ISSN 2045-2322], v. 8, article number 3016 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.title | N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41598-018-21099-1 | en_US |
dc.identifier.pmid | 8 | - |
dc.identifier.scopus | 85042133592 | - |
dc.identifier.isi | 000424985800054 | - |
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dc.contributor.orcid | #NODATA# | - |
dc.contributor.authorscopusid | 7005000190 | - |
dc.contributor.authorscopusid | 35148038500 | - |
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dc.contributor.authorscopusid | 7005720583 | - |
dc.contributor.authorscopusid | 57194076155 | - |
dc.identifier.issue | 3016 | - |
dc.relation.volume | 8 | en_US |
dc.investigacion | Ciencias de la Salud | - |
dc.type2 | Artículo | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 1,414 | |
dc.description.jcr | 4,011 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Con texto completo | - |
item.grantfulltext | open | - |
crisitem.project.principalinvestigator | López Calbet, José Antonio | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.orcid | 0000-0001-8463-397X | - |
crisitem.author.orcid | 0000-0002-3685-2331 | - |
crisitem.author.orcid | 0000-0002-9190-2581 | - |
crisitem.author.orcid | 0000-0002-9215-6234 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Morales Álamo, David | - |
crisitem.author.fullName | Martín Rincón, Marcos | - |
crisitem.author.fullName | De Pablos Velasco, Pedro Luis | - |
crisitem.author.fullName | López Calbet, José Antonio | - |
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