Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44467
|Title:||N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism||Authors:||Ström, Kristoffer
Jörgensen, Sine W.
De Pablos-Velasco, Pedro
Stenkula, Karin G.
Holmberg, Hans Christer
Calbet, Jose A.
|UNESCO Clasification:||32 Ciencias médicas||Issue Date:||2018||Project:||Viabilidad y Sostenibilidad Del Adelgazamiento Mediante Tratamiento Intensificado en Pacientes Con Sobrepeso U Obesidad: Mecanismos Neuroendocrinos y Moleculares||Journal:||Scientific Reports||Abstract:||Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism. Nicotinamide N-methyltransferase (NNMT) was the most consistently upregulated gene following the energy-deficit exercise. Circulating levels of N-1-methylnicotinamide (MNA), the product of NNMT activity, were doubled after the intervention. The fasting-fed state was an important determinant of plasma MNA levels, peaking at similar to 18 h of fasting and being lowest similar to 3 h after a meal. In culture, MNA was secreted by isolated human myotubes and stimulated lipolysis directly, with no effect on glucagon or insulin secretion. We propose that MNA is a novel myokine that enhances the utilization of energy stores in response to low muscle energy availability. Future research should focus on applying MNA as a biomarker to identify individuals with metabolic disturbances at an early stage.||URI:||http://hdl.handle.net/10553/41846||ISSN:||2045-2322||DOI:||10.1038/s41598-018-21099-1||Source:||Scientific Reports [ISSN 2045-2322], v. 8, article number 3016|
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