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Title: The nuclear receptor LXRα controls the functional specialization of splenic macrophages
Authors: A-Gonzalez, Noelia
Guillén, José Ángel 
Gallardo Campos, Germán 
Díaz-Sarmiento, Mercedes 
de la Rosa, Juan Vladimir 
Hernández Hernández, Irene 
Casanova-Acebes, Maria
López Blanco, Félix 
Tabraue Tarbay, Carlos 
Beceiro Casas, Susana 
Hong, Cynthia
Lara Jiménez, Pedro Carlos 
Andujar Sanchez, Miguel 
Arai, Satoko
Miyazaki, Toru
Li, Senlin
Corbi, Angel L.
Tontonoz, Peter
Hidalgo, Andres
Castrillo, Antonio 
UNESCO Clasification: 32 Ciencias médicas
2409 Genética
Keywords: Monocytes and macrophages
Issue Date: 2013
Journal: Nature Immunology 
Abstract: Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was essential for the differentiation of macrophages in the marginal zone (MZ) of the spleen. LXR-deficient mice were defective in the generation of MZ and metallophilic macrophages, which resulted in abnormal responses to blood-borne antigens. Myeloid-specific expression of LXRα or adoptive transfer of wild-type monocytes restored the MZ microenvironment in LXRα-deficient mice. Our results demonstrate that signaling via LXRα in myeloid cells is crucial for the generation of splenic MZ macrophages and identify an unprecedented role for a nuclear receptor in the generation of specialized macrophage subsets.
ISSN: 1529-2908
DOI: 10.1038/ni.2622
Source: Nature Immunology [ISSN 1529-2908], v. 14 (8), p. 831-839
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