Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/44413
DC Field | Value | Language |
---|---|---|
dc.contributor.author | A-Gonzalez, Noelia | en_US |
dc.contributor.author | Guillén, José Ángel | en_US |
dc.contributor.author | Gallardo Campos, Germán | en_US |
dc.contributor.author | Díaz-Sarmiento, Mercedes | en_US |
dc.contributor.author | de la Rosa, Juan Vladimir | en_US |
dc.contributor.author | Hernández Hernández, Irene | en_US |
dc.contributor.author | Casanova-Acebes, Maria | en_US |
dc.contributor.author | López Blanco, Félix | en_US |
dc.contributor.author | Tabraue Tarbay, Carlos | en_US |
dc.contributor.author | Beceiro Casas, Susana | en_US |
dc.contributor.author | Hong, Cynthia | en_US |
dc.contributor.author | Lara Jiménez, Pedro Carlos | en_US |
dc.contributor.author | Andujar Sanchez, Miguel | en_US |
dc.contributor.author | Arai, Satoko | en_US |
dc.contributor.author | Miyazaki, Toru | en_US |
dc.contributor.author | Li, Senlin | en_US |
dc.contributor.author | Corbi, Angel L. | en_US |
dc.contributor.author | Tontonoz, Peter | en_US |
dc.contributor.author | Hidalgo, Andres | en_US |
dc.contributor.author | Castrillo, Antonio | en_US |
dc.contributor.other | Hernandez, Irene | - |
dc.contributor.other | Tabraue, Carlos | - |
dc.contributor.other | Corbi, Angel | - |
dc.contributor.other | Hidalgo, Andres | - |
dc.contributor.other | Alonso Gonzalez, Noelia | - |
dc.date.accessioned | 2018-11-21T22:51:57Z | - |
dc.date.available | 2018-11-21T22:51:57Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.issn | 1529-2908 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/44413 | - |
dc.description.abstract | Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was essential for the differentiation of macrophages in the marginal zone (MZ) of the spleen. LXR-deficient mice were defective in the generation of MZ and metallophilic macrophages, which resulted in abnormal responses to blood-borne antigens. Myeloid-specific expression of LXRα or adoptive transfer of wild-type monocytes restored the MZ microenvironment in LXRα-deficient mice. Our results demonstrate that signaling via LXRα in myeloid cells is crucial for the generation of splenic MZ macrophages and identify an unprecedented role for a nuclear receptor in the generation of specialized macrophage subsets. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Nature Immunology | en_US |
dc.source | Nature Immunology [ISSN 1529-2908], v. 14 (8), p. 831-839 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 2409 Genética | en_US |
dc.subject.other | Monocytes and macrophages | en_US |
dc.subject.other | Spleen | en_US |
dc.title | The nuclear receptor LXRα controls the functional specialization of splenic macrophages | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/ni.2622 | en_US |
dc.identifier.pmid | 14 | - |
dc.identifier.scopus | 84880846105 | - |
dc.identifier.isi | 000322010600012 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dcterms.isPartOf | Nature Immunology | - |
dcterms.source | Nature Immunology[ISSN 1529-2908],v. 14 (8), p. 831-+ | - |
dc.contributor.authorscopusid | 28567533000 | - |
dc.contributor.authorscopusid | 57192957894 | - |
dc.contributor.authorscopusid | 55926670100 | - |
dc.contributor.authorscopusid | 6603046608 | - |
dc.contributor.authorscopusid | 35084829700 | - |
dc.contributor.authorscopusid | 55926663500 | - |
dc.contributor.authorscopusid | 57201434068 | - |
dc.contributor.authorscopusid | 55750584600 | - |
dc.contributor.authorscopusid | 6602478628 | - |
dc.contributor.authorscopusid | 7202047893 | - |
dc.contributor.authorscopusid | 6506833060 | - |
dc.contributor.authorscopusid | 35084862100 | - |
dc.contributor.authorscopusid | 15755660400 | - |
dc.contributor.authorscopusid | 7004374085 | - |
dc.contributor.authorscopusid | 7004631953 | - |
dc.contributor.authorscopusid | 8837386200 | - |
dc.contributor.authorscopusid | 7404107752 | - |
dc.contributor.authorscopusid | 7409243672 | - |
dc.contributor.authorscopusid | 7005390980 | - |
dc.contributor.authorscopusid | 7007079890 | - |
dc.contributor.authorscopusid | 7102781677 | - |
dc.contributor.authorscopusid | 55445301000 | - |
dc.description.lastpage | 839 | en_US |
dc.identifier.issue | 8 | - |
dc.description.firstpage | 831 | en_US |
dc.relation.volume | 14 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000322010600012 | - |
dc.contributor.daisngid | 34354606 | - |
dc.contributor.daisngid | 4004716 | - |
dc.contributor.daisngid | 5734696 | - |
dc.contributor.daisngid | 7801524 | - |
dc.contributor.daisngid | 5756470 | - |
dc.contributor.daisngid | 6668944 | - |
dc.contributor.daisngid | 462854 | - |
dc.contributor.daisngid | 4455245 | - |
dc.contributor.daisngid | 2864371 | - |
dc.contributor.daisngid | 6657726 | - |
dc.contributor.daisngid | 4816905 | - |
dc.contributor.daisngid | 3913413 | - |
dc.contributor.daisngid | 750105 | - |
dc.contributor.daisngid | 591076 | - |
dc.contributor.daisngid | 990803 | - |
dc.contributor.daisngid | 763759 | - |
dc.contributor.daisngid | 2551845 | - |
dc.contributor.daisngid | 27847312 | - |
dc.contributor.daisngid | 2676964 | - |
dc.contributor.daisngid | 201243 | - |
dc.contributor.daisngid | 103250 | - |
dc.contributor.daisngid | 39535 | - |
dc.contributor.daisngid | 225640 | - |
dc.identifier.investigatorRID | N-7551-2016 | - |
dc.identifier.investigatorRID | D-7126-2015 | - |
dc.identifier.investigatorRID | B-7194-2011 | - |
dc.identifier.investigatorRID | L-5643-2014 | - |
dc.identifier.investigatorRID | H-4488-2015 | - |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:A-Gonzalez, N | - |
dc.contributor.wosstandard | WOS:Guillen, JA | - |
dc.contributor.wosstandard | WOS:Gallardo, G | - |
dc.contributor.wosstandard | WOS:Diaz, M | - |
dc.contributor.wosstandard | WOS:de la Rosa, JV | - |
dc.contributor.wosstandard | WOS:Hernandez, IH | - |
dc.contributor.wosstandard | WOS:Casanova-Acebes, M | - |
dc.contributor.wosstandard | WOS:Lopez, F | - |
dc.contributor.wosstandard | WOS:Tabraue, C | - |
dc.contributor.wosstandard | WOS:Beceiro, S | - |
dc.contributor.wosstandard | WOS:Hong, C | - |
dc.contributor.wosstandard | WOS:Lara, PC | - |
dc.contributor.wosstandard | WOS:Andujar, M | - |
dc.contributor.wosstandard | WOS:Arai, S | - |
dc.contributor.wosstandard | WOS:Miyazaki, T | - |
dc.contributor.wosstandard | WOS:Li, SL | - |
dc.contributor.wosstandard | WOS:Corbi, AL | - |
dc.contributor.wosstandard | WOS:Tontonoz, P | - |
dc.contributor.wosstandard | WOS:Hidalgo, A | - |
dc.contributor.wosstandard | WOS:Castrillo, A | - |
dc.date.coverdate | Agosto 2013 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.description.sjr | 14,784 | |
dc.description.sjrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IATEXT: Didáctica, Aprendizaje y Motivación en Contextos Específicos | - |
crisitem.author.dept | IU de Análisis y Aplicaciones Textuales | - |
crisitem.author.dept | Departamento de Didácticas Específicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUIBS: Diabetes y endocrinología aplicada | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0003-4220-2471 | - |
crisitem.author.orcid | 0000-0002-1516-1750 | - |
crisitem.author.orcid | 0000-0003-1443-7548 | - |
crisitem.author.orcid | 0000-0001-7174-7599 | - |
crisitem.author.orcid | 0000-0003-1167-9787 | - |
crisitem.author.orcid | 0000-0001-9920-8116 | - |
crisitem.author.orcid | 0000-0002-4858-6915 | - |
crisitem.author.orcid | 0000-0002-2057-2159 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Análisis y Aplicaciones Textuales | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Guillén Salgado, José Ángel | - |
crisitem.author.fullName | Gallardo Campos, Germán | - |
crisitem.author.fullName | Diaz Sarmiento,Maria Mercedes | - |
crisitem.author.fullName | De La Rosa Medina, Juan Vladimir | - |
crisitem.author.fullName | Hernández Hernández,Irene | - |
crisitem.author.fullName | López Blanco, Félix | - |
crisitem.author.fullName | Tabraue Tarbay, Carlos | - |
crisitem.author.fullName | Beceiro Casas, Susana | - |
crisitem.author.fullName | Lara Jiménez, Pedro Carlos | - |
crisitem.author.fullName | Andujar Sanchez,Miguel | - |
crisitem.author.fullName | Castrillo Viguera, Antonio Jesús | - |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
136
checked on Nov 17, 2024
WEB OF SCIENCETM
Citations
131
checked on Nov 17, 2024
Page view(s)
100
checked on Mar 9, 2024
Download(s)
95
checked on Mar 9, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.