Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44413
DC FieldValueLanguage
dc.contributor.authorA-Gonzalez, Noelia-
dc.contributor.authorGuillen Salgado, Jose A.-
dc.contributor.authorGallardo Campos, Germán-
dc.contributor.authorDíaz Sarmiento, María Mercedes-
dc.contributor.authorde la Rosa, Juan Vladimir-
dc.contributor.authorHernández Hernández, Irene-
dc.contributor.authorCasanova-Acebes, Maria-
dc.contributor.authorLópez Blanco, Félix-
dc.contributor.authorTabraue Tarbay, Carlos-
dc.contributor.authorBeceiro Casas, Susana-
dc.contributor.authorHong, Cynthia-
dc.contributor.authorLara Jiménez, Pedro Carlos-
dc.contributor.authorAndujar Sanchez, Miguel-
dc.contributor.authorArai, Satoko-
dc.contributor.authorMiyazaki, Toru-
dc.contributor.authorLi, Senlin-
dc.contributor.authorCorbi, Angel L.-
dc.contributor.authorTontonoz, Peter-
dc.contributor.authorHidalgo, Andres-
dc.contributor.authorCastrillo, Antonio-
dc.contributor.otherHernandez, Irene-
dc.contributor.otherTabraue, Carlos-
dc.contributor.otherCorbi, Angel-
dc.contributor.otherHidalgo, Andres-
dc.contributor.otherAlonso Gonzalez, Noelia-
dc.date.accessioned2018-11-21T22:51:57Z-
dc.date.available2018-11-21T22:51:57Z-
dc.date.issued2013-
dc.identifier.issn1529-2908-
dc.identifier.urihttp://hdl.handle.net/10553/44413-
dc.description.abstractMacrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was essential for the differentiation of macrophages in the marginal zone (MZ) of the spleen. LXR-deficient mice were defective in the generation of MZ and metallophilic macrophages, which resulted in abnormal responses to blood-borne antigens. Myeloid-specific expression of LXRα or adoptive transfer of wild-type monocytes restored the MZ microenvironment in LXRα-deficient mice. Our results demonstrate that signaling via LXRα in myeloid cells is crucial for the generation of splenic MZ macrophages and identify an unprecedented role for a nuclear receptor in the generation of specialized macrophage subsets.-
dc.languageeng-
dc.publisher1529-2908-
dc.relation.ispartofNature Immunology-
dc.sourceNature Immunology [ISSN 1529-2908], v. 14 (8), p. 831-839-
dc.subject32 Ciencias médicas-
dc.subject2409 Genética-
dc.subject.otherLiver X Receptors
dc.subject.otherGene-Expression
dc.subject.otherMyeloid Cells
dc.subject.otherMonocytes
dc.subject.otherMetabolism
dc.subject.otherProliferation
dc.subject.otherInflammation
dc.subject.otherRetention
dc.subject.otherReveals
dc.subject.otherProtein
dc.titleThe nuclear receptor LXRα controls the functional specialization of splenic macrophages-
dc.typeinfo:eu-repo/semantics/Article-
dc.typeArticle-
dc.identifier.doi10.1038/ni.2622
dc.identifier.pmid14-
dc.identifier.scopus84880846105-
dc.identifier.isi000322010600012-
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dcterms.isPartOfNature Immunology-
dcterms.sourceNature Immunology[ISSN 1529-2908],v. 14 (8), p. 831-+-
dc.contributor.authorscopusid28567533000-
dc.contributor.authorscopusid57192957894
dc.contributor.authorscopusid55926670100-
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dc.contributor.authorscopusid57201434068-
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dc.contributor.authorscopusid7202047893-
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dc.contributor.authorscopusid35084862100-
dc.contributor.authorscopusid15755660400-
dc.contributor.authorscopusid7004374085-
dc.contributor.authorscopusid7004631953-
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dc.contributor.authorscopusid7404107752-
dc.contributor.authorscopusid7409243672-
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dc.contributor.authorscopusid7007079890-
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dc.contributor.authorscopusid55445301000-
dc.description.lastpage839-
dc.identifier.issue8-
dc.description.firstpage831-
dc.relation.volume14-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.identifier.wosWOS:000322010600012-
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dc.contributor.daisngid201243-
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dc.contributor.daisngid39535-
dc.contributor.daisngid225640-
dc.identifier.investigatorRIDN-7551-2016-
dc.identifier.investigatorRIDD-7126-2015-
dc.identifier.investigatorRIDB-7194-2011-
dc.identifier.investigatorRIDL-5643-2014-
dc.identifier.investigatorRIDH-4488-2015-
dc.utils.revision-
dc.contributor.wosstandardWOS:A-Gonzalez, N
dc.contributor.wosstandardWOS:Guillen, JA
dc.contributor.wosstandardWOS:Gallardo, G
dc.contributor.wosstandardWOS:Diaz, M
dc.contributor.wosstandardWOS:de la Rosa, JV
dc.contributor.wosstandardWOS:Hernandez, IH
dc.contributor.wosstandardWOS:Casanova-Acebes, M
dc.contributor.wosstandardWOS:Lopez, F
dc.contributor.wosstandardWOS:Tabraue, C
dc.contributor.wosstandardWOS:Beceiro, S
dc.contributor.wosstandardWOS:Hong, C
dc.contributor.wosstandardWOS:Lara, PC
dc.contributor.wosstandardWOS:Andujar, M
dc.contributor.wosstandardWOS:Arai, S
dc.contributor.wosstandardWOS:Miyazaki, T
dc.contributor.wosstandardWOS:Li, SL
dc.contributor.wosstandardWOS:Corbi, AL
dc.contributor.wosstandardWOS:Tontonoz, P
dc.contributor.wosstandardWOS:Hidalgo, A
dc.contributor.wosstandardWOS:Castrillo, A
dc.date.coverdateAgosto 2013
dc.identifier.ulpgces
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Didácticas Específicas-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-3878-3867-
crisitem.author.orcid0000-0003-1443-7548-
crisitem.author.orcid0000-0001-7174-7599-
crisitem.author.orcid0000-0001-9920-8116-
crisitem.author.orcid0000-0002-4858-6915-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGuillén Salgado, José Ángel-
crisitem.author.fullNameGallardo Campos, Germán-
crisitem.author.fullNameDiaz Cabrera, Moises-
crisitem.author.fullNameDe La Rosa Medina, Juan Vladimir-
crisitem.author.fullNameHernández Hernández, Irene-
crisitem.author.fullNameLópez Blanco, Félix-
crisitem.author.fullNameTabraue Tarbay, Carlos-
crisitem.author.fullNameBeceiro Casas, Susana-
crisitem.author.fullNameLara Jiménez, Pedro Carlos-
crisitem.author.fullNameAndujar Sanchez, Miguel-
crisitem.author.fullNameCastrillo Viguera, Antonio Jesús-
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