Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43480
Title: Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling
Authors: Rubio Sánchez, Sara 
León, Francisco
Quintana Aguiar, José Martín 
Cutler, Stephen
Estévez Rosas, Francisco Jesús 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Apoptosis
Caspases
Cell cycle
Cytotoxicity
Issue Date: 2012
Publisher: 0223-5234
Project: Evaluación de Potenciales Compuestos Antileucémicos. 
Journal: European Journal of Medicinal Chemistry 
Abstract: A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2' of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G(1) cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.
URI: http://hdl.handle.net/10553/43480
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2012.07.028
Source: European Journal of Medicinal Chemistry [ISSN 0223-5234], v. 55, p. 284-296
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