Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43480
Campo DC Valoridioma
dc.contributor.authorRubio Sánchez, Saraen_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.contributor.authorCutler, Stephenen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherRubio, Sara-
dc.contributor.otherRUBIO SANCHEZ, SARA-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-21T15:29:58Z-
dc.date.available2018-11-21T15:29:58Z-
dc.date.issued2012en_US
dc.identifier.issn0223-5234en_US
dc.identifier.urihttp://hdl.handle.net/10553/43480-
dc.description.abstractA new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2' of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G(1) cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.en_US
dc.languageengen_US
dc.publisher0223-5234-
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.sourceEuropean Journal of Medicinal Chemistry [ISSN 0223-5234], v. 55, p. 284-296en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherApoptosisen_US
dc.subject.otherCaspasesen_US
dc.subject.otherCell cycleen_US
dc.subject.otherCytotoxicityen_US
dc.titleCell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signalingen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejmech.2012.07.028en_US
dc.identifier.scopus84865755962-
dc.identifier.isi000309494100030-
dcterms.isPartOfEuropean Journal Of Medicinal Chemistry-
dcterms.sourceEuropean Journal Of Medicinal Chemistry[ISSN 0223-5234],v. 55, p. 284-296-
dc.contributor.authorscopusid22635323400-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid36183236500-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage296en_US
dc.description.firstpage284en_US
dc.relation.volume55en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000309494100030-
dc.contributor.daisngid4276242-
dc.contributor.daisngid136703-
dc.contributor.daisngid128315-
dc.contributor.daisngid59825-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-4656-2013-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Rubio, S-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Cutler, S-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateSeptiembre 2012en_US
dc.identifier.ulpgces
dc.description.sjr1,201
dc.description.jcr3,499
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-7633-1285-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRubio Sánchez, Sara-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
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