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Title: Immunohistochemical labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniae
Authors: Rodríguez Guisado, Francisco 
Ramírez, G. A.
Sarradell, J.
Andrada Borzollino, Marisa Ana 
Lorenzo, H.
UNESCO Clasification: 310907 Patología
Keywords: Bacterial infection
Mycoplasma hyopneumoniae
Porcine enzootic pneumonia
Issue Date: 2004
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Mycoplasma hyopneumoniae (Mh) is the primary agent of porcine enzootic pneumonia (PEN), a chronic respiratory disease endemic to pig farms, and characterized histologically by infiltration of mononuclear cells in airways and prominent hyperplasia of the bronchus-associated lymphoid tissue (BALT). To gain further insight into the pathogenesis of PEN, cytokine expression in the lung, with particular attention to the BALT, was examined immunohistochemically in pigs naturally infected with Mh. An increase (P<0.05) in proinflammatory and immunoregulatory cytokines (especially interleukin [IL]-2, IL-4 and tumour necrosis factor [TNF]-α, and to a lesser extent IL-1 [α and β] and IL-6) was detected in the BALT, which showed intense lymphoid hyperplasia. IL-1β and TNF-α were also detected in the bronchoalveolar exudate of infected pigs, and IL-6 and IL-8 were demonstrated in mononuclear cells of the alveolar septa. The results showed that in Mh infection, macrophage and lymphocyte activation results in the expression of a number of cytokines capable of inducing lung lesions and lymphoreticular hyperplasia of the BALT.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2003.12.008
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 130(4), p. 306-312
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