Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43373
DC FieldValueLanguage
dc.contributor.authorRodríguez Guisado, Franciscoen_US
dc.contributor.authorRamírez, G. A.en_US
dc.contributor.authorSarradell, J.en_US
dc.contributor.authorAndrada Borzollino, Marisa Anaen_US
dc.contributor.authorLorenzo, H.en_US
dc.date.accessioned2018-11-21T14:39:43Z-
dc.date.available2018-11-21T14:39:43Z-
dc.date.issued2004en_US
dc.identifier.issn0021-9975en_US
dc.identifier.urihttp://hdl.handle.net/10553/43373-
dc.description.abstractMycoplasma hyopneumoniae (Mh) is the primary agent of porcine enzootic pneumonia (PEN), a chronic respiratory disease endemic to pig farms, and characterized histologically by infiltration of mononuclear cells in airways and prominent hyperplasia of the bronchus-associated lymphoid tissue (BALT). To gain further insight into the pathogenesis of PEN, cytokine expression in the lung, with particular attention to the BALT, was examined immunohistochemically in pigs naturally infected with Mh. An increase (P<0.05) in proinflammatory and immunoregulatory cytokines (especially interleukin [IL]-2, IL-4 and tumour necrosis factor [TNF]-α, and to a lesser extent IL-1 [α and β] and IL-6) was detected in the BALT, which showed intense lymphoid hyperplasia. IL-1β and TNF-α were also detected in the bronchoalveolar exudate of infected pigs, and IL-6 and IL-8 were demonstrated in mononuclear cells of the alveolar septa. The results showed that in Mh infection, macrophage and lymphocyte activation results in the expression of a number of cytokines capable of inducing lung lesions and lymphoreticular hyperplasia of the BALT.en_US
dc.languageengen_US
dc.publisher0021-9975-
dc.relation.ispartofJournal of Comparative Pathologyen_US
dc.sourceJournal of Comparative Pathology [ISSN 0021-9975], v. 130(4), p. 306-312en_US
dc.subject310907 Patologíaen_US
dc.subject.otherBacterial infectionen_US
dc.subject.otherCytokineen_US
dc.subject.otherMycoplasma hyopneumoniaeen_US
dc.subject.otherPigen_US
dc.subject.otherPorcine enzootic pneumoniaen_US
dc.titleImmunohistochemical labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniaeen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.jcpa.2003.12.008-
dc.identifier.scopus1842639413-
dc.identifier.isi000220833900009-
dc.contributor.authorscopusid21641919200-
dc.contributor.authorscopusid25623593400-
dc.contributor.authorscopusid6602259861-
dc.contributor.authorscopusid6602991535-
dc.contributor.authorscopusid6603882730-
dc.description.lastpage312-
dc.description.firstpage306-
dc.relation.volume130-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2263409-
dc.contributor.daisngid389144-
dc.contributor.daisngid3902685-
dc.contributor.daisngid862879-
dc.contributor.daisngid4983330-
dc.contributor.wosstandardWOS:Rodriguez, F-
dc.contributor.wosstandardWOS:Ramirez, GA-
dc.contributor.wosstandardWOS:Sarradell, J-
dc.contributor.wosstandardWOS:Andrada, M-
dc.contributor.wosstandardWOS:Lorenzo, H-
dc.date.coverdateEnero 2004-
dc.identifier.ulpgces
dc.description.jcr1,365
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-4968-5333-
crisitem.author.orcid0000-0002-2411-9714-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameRodríguez Guisado, Francisco-
crisitem.author.fullNameAndrada Borzollino, Marisa Ana-
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