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Title: Cyclooxygenase-2 Expression in Pigs Infected Experimentally with Mycoplasma hyopneumoniae
Authors: Andrada Borzollino, Marisa Ana 
Quesada Canales, Ildefonso Óscar 
Suarez Bonnet, Alejandro 
Paz Sanchez, Yania 
Espinosa de los Monteros y Zayas, Antonio 
Rodríguez Guisado, Francisco 
UNESCO Clasification: 310907 Patología
Keywords: Cyclooxygenase-2
Mycoplasma hyopneumoniae
Issue Date: 2014
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Porcine enzootic pneumonia, primarily caused by Mycoplasma hyopneumoniae (Mh), is a contagious disease characterized by catarrhal bronchointerstitial pneumonia. Previous studies have evaluated immunohistochemically the distribution of Mh, different cellular populations and cytokines during Mh-induced pneumonia. Cyclooxygenase (COX)-2 is overexpressed during inflammatory responses by different cell types in the lung. The aim of this study was to elucidate the possible role of COX-2 in the pathogenesis of porcine enzootic pneumonia. COX-2 protein was detected by immunohistochemistry in formalin-fixed, paraffin wax-embedded lung tissues from 10 pigs infected experimentally with Mh. Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 1 to 5 weeks post inoculation. Three Mh-free pigs were taken as controls. Bronchial and bronchiolar epithelial cells, bronchial submucosal glands and a small number of macrophages in the bronchoalveolar exudate expressed COX-2. COX-2 protein was always associated with areas of pneumonia and expression was minimal in lungs from control pigs. These results suggest that COX-2 plays a role in the pathogenesis of Mh-infection.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2014.04.005
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 151(2-3), p. 271-276
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