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http://hdl.handle.net/10553/43343
Title: | Cyclooxygenase-2 Expression in Pigs Infected Experimentally with Mycoplasma hyopneumoniae | Authors: | Andrada Borzollino, Marisa Ana Quesada Canales, Ildefonso Óscar Suarez Bonnet, Alejandro Paz Sanchez, Yania Espinosa de los Monteros y Zayas, Antonio Rodríguez Guisado, Francisco |
UNESCO Clasification: | 310907 Patología | Keywords: | Cyclooxygenase-2 Mycoplasma hyopneumoniae Pig Pneumonia |
Issue Date: | 2014 | Publisher: | 0021-9975 | Journal: | Journal of Comparative Pathology | Abstract: | Porcine enzootic pneumonia, primarily caused by Mycoplasma hyopneumoniae (Mh), is a contagious disease characterized by catarrhal bronchointerstitial pneumonia. Previous studies have evaluated immunohistochemically the distribution of Mh, different cellular populations and cytokines during Mh-induced pneumonia. Cyclooxygenase (COX)-2 is overexpressed during inflammatory responses by different cell types in the lung. The aim of this study was to elucidate the possible role of COX-2 in the pathogenesis of porcine enzootic pneumonia. COX-2 protein was detected by immunohistochemistry in formalin-fixed, paraffin wax-embedded lung tissues from 10 pigs infected experimentally with Mh. Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 1 to 5 weeks post inoculation. Three Mh-free pigs were taken as controls. Bronchial and bronchiolar epithelial cells, bronchial submucosal glands and a small number of macrophages in the bronchoalveolar exudate expressed COX-2. COX-2 protein was always associated with areas of pneumonia and expression was minimal in lungs from control pigs. These results suggest that COX-2 plays a role in the pathogenesis of Mh-infection. | URI: | http://hdl.handle.net/10553/43343 | ISSN: | 0021-9975 | DOI: | 10.1016/j.jcpa.2014.04.005 | Source: | Journal of Comparative Pathology [ISSN 0021-9975], v. 151(2-3), p. 271-276 |
Appears in Collections: | Artículos |
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