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Title: Immunohistochemical Detection of Interleukin-12 and Interferon-γ in Pigs Experimentally Infected with Mycoplasma hyopneumoniae
Authors: Rodríguez Guisado, Francisco 
Quesada Canales, Ildefonso Óscar 
Poveda Guerrero, José Bismarck 
Fernández Rodríguez, Antonio Jesús 
Lorenzo, H.
UNESCO Clasification: 310907 Patología
Keywords: Cytokines in pneumonia
Mycoplasma hyopneumoniae
Issue Date: 2007
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: The expression of interleukin-12 (IL-12) and interferon-gamma (IFN-γ) was examined immunohistochemically in the lungs of pigs aged 21 days infected experimentally with Mycoplasma hyopneumoniae (Mh). Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 7 to 35 days post-infection (dpi). Immunolabelling for IL-12 and IFN-γ was usually associated with inflammation, particularly in macrophages and lymphocytes in the thickened alveolar septa and in the hyperplastic bronchus-associated lymphoid tissue (BALT). Cells positive for both cytokines were detected at 7 dpi, their numbers increasing at 14 and 21 dpi, and slightly decreasing thereafter. The results suggest that IL-12 and IFN-γ play a role in pulmonary defence mechanisms against Mh infection.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2006.11.001
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 136(1), p. 79-82
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