|Title:||Immunohistochemical Detection of Interleukin-12 and Interferon-γ in Pigs Experimentally Infected with Mycoplasma hyopneumoniae||Authors:||Rodríguez Guisado, Francisco
Quesada Canales, Ildefonso Óscar
Poveda Guerrero, José Bismarck
Fernández Rodríguez, Antonio Jesús
|UNESCO Clasification:||310907 Patología||Keywords:||Cytokines in pneumonia
|Issue Date:||2007||Publisher:||0021-9975||Journal:||Journal of Comparative Pathology||Abstract:||The expression of interleukin-12 (IL-12) and interferon-gamma (IFN-γ) was examined immunohistochemically in the lungs of pigs aged 21 days infected experimentally with Mycoplasma hyopneumoniae (Mh). Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 7 to 35 days post-infection (dpi). Immunolabelling for IL-12 and IFN-γ was usually associated with inflammation, particularly in macrophages and lymphocytes in the thickened alveolar septa and in the hyperplastic bronchus-associated lymphoid tissue (BALT). Cells positive for both cytokines were detected at 7 dpi, their numbers increasing at 14 and 21 dpi, and slightly decreasing thereafter. The results suggest that IL-12 and IFN-γ play a role in pulmonary defence mechanisms against Mh infection.||URI:||http://hdl.handle.net/10553/43196||ISSN:||0021-9975||DOI:||10.1016/j.jcpa.2006.11.001||Source:||Journal of Comparative Pathology [ISSN 0021-9975], v. 136(1), p. 79-82|
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