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Title: | Immunohistochemical detection of interleukin-12 and interferon-gamma in pigs experimentally infected with Mycoplasma hyopneumoniae | Other Titles: | Immunohistochemical Detection of Interleukin-12 and Interferon-γ in Pigs Experimentally Infected with Mycoplasma hyopneumoniae | Authors: | Rodríguez Guisado, Francisco Quesada Canales, Ildefonso Óscar Poveda Guerrero, José Bismarck Fernández Rodríguez, Antonio Jesús Lorenzo, H. |
UNESCO Clasification: | 310907 Patología | Keywords: | Cytokines in pneumonia Mycoplasma hyopneumoniae Pig |
Issue Date: | 2007 | Publisher: | 0021-9975 | Journal: | Journal of Comparative Pathology | Abstract: | The expression of interleukin-12 (IL-12) and interferon-gamma (IFN-γ) was examined immunohistochemically in the lungs of pigs aged 21 days infected experimentally with Mycoplasma hyopneumoniae (Mh). Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 7 to 35 days post-infection (dpi). Immunolabelling for IL-12 and IFN-γ was usually associated with inflammation, particularly in macrophages and lymphocytes in the thickened alveolar septa and in the hyperplastic bronchus-associated lymphoid tissue (BALT). Cells positive for both cytokines were detected at 7 dpi, their numbers increasing at 14 and 21 dpi, and slightly decreasing thereafter. The results suggest that IL-12 and IFN-γ play a role in pulmonary defence mechanisms against Mh infection. | URI: | http://hdl.handle.net/10553/43196 | ISSN: | 0021-9975 | DOI: | 10.1016/j.jcpa.2006.11.001 | Source: | Journal of Comparative Pathology [ISSN 0021-9975], v. 136(1), p. 79-82 |
Appears in Collections: | Artículos |
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