Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43050
Title: Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients
Authors: Henríquez-Hernández, Luis Alberto 
Pinar, Beatriz
Carmona-Vigo, Ruth
Bordón, Elisa 
Rodríguez-Gallego, Carlos 
Flores-Morales, Amílcar 
Lara, Pedro C.
Keywords: Radio-Induced Apoptosis
Double-Strand Breaks
Long-Term Toxicity
Ionizing-Radiation
Clinical Toxicity, et al
Issue Date: 2013
Publisher: 0960-9776
Journal: Breast 
Abstract: Purpose: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes.Patients and methods: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray.Results: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p < 0.01). Forty-two genes segregated patients according to radiation-induced apoptosis (p < 0.01). We found common canonical pathways and common biological processes significantly regulated between both set of genes.Conclusion: We introduced new data in the field of molecular genomics regarding to the relation established between radiation toxicity and these predictive factors to radiation injury. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/43050
ISSN: 0960-9776
DOI: 10.1016/j.breast.2012.05.005
Source: Breast[ISSN 0960-9776],v. 22, p. 28-33
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