Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43050
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dc.contributor.authorHenríquez-Hernández, Luis Alberto
dc.contributor.authorPinar, Beatriz
dc.contributor.authorCarmona-Vigo, Ruth
dc.contributor.authorBordón, Elisa
dc.contributor.authorRodríguez-Gallego, Carlos
dc.contributor.authorFlores-Morales, Amílcar
dc.contributor.authorLara, Pedro C.
dc.date.accessioned2018-11-21T12:15:42Z-
dc.date.available2018-11-21T12:15:42Z-
dc.date.issued2013
dc.identifier.issn0960-9776
dc.identifier.urihttp://hdl.handle.net/10553/43050-
dc.description.abstractPurpose: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes.Patients and methods: Twelve consecutive patients suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray.Results: Thirty-four constitutive genes segregated patients with lower DNA-double strand break from those patients with higher DNA-double strand break (p < 0.01). Forty-two genes segregated patients according to radiation-induced apoptosis (p < 0.01). We found common canonical pathways and common biological processes significantly regulated between both set of genes.Conclusion: We introduced new data in the field of molecular genomics regarding to the relation established between radiation toxicity and these predictive factors to radiation injury. (C) 2012 Elsevier Ltd. All rights reserved.
dc.publisher0960-9776
dc.relation.ispartofBreast
dc.sourceBreast[ISSN 0960-9776],v. 22, p. 28-33
dc.subject.otherRadio-Induced Apoptosis
dc.subject.otherDouble-Strand Breaks
dc.subject.otherLong-Term Toxicity
dc.subject.otherIonizing-Radiation
dc.subject.otherClinical Toxicity
dc.subject.otherAtm Gene
dc.subject.otherRadiosensitivity
dc.subject.otherRadiotherapy
dc.subject.otherPrediction
dc.subject.otherMutations
dc.titleCommon genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.breast.2012.05.005
dc.identifier.scopus84871719973-
dc.identifier.isi000314389200005
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid6507421079
dc.contributor.authorscopusid38960985000
dc.contributor.authorscopusid24402677200
dc.contributor.authorscopusid6602114379
dc.contributor.authorscopusid57203543387
dc.contributor.authorscopusid57203543352
dc.contributor.authorscopusid7004374085
dc.description.lastpage33
dc.description.firstpage28
dc.relation.volume22
dc.type2Artículoes
dc.contributor.daisngid465624
dc.contributor.daisngid1285881
dc.contributor.daisngid16760579
dc.contributor.daisngid2045042
dc.contributor.daisngid603384
dc.contributor.daisngid617657
dc.contributor.daisngid591076
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Pinar, B
dc.contributor.wosstandardWOS:Carrnona-Vigo, R
dc.contributor.wosstandardWOS:Bordon, E
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C
dc.contributor.wosstandardWOS:Flores-Morales, A
dc.contributor.wosstandardWOS:Lara, PC
dc.date.coverdateEnero 2013
dc.identifier.ulpgces
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-0828-8921-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameBordón Rodríguez, Elisa de los Reyes-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
crisitem.author.fullNameFlores Morales, Amilcar-
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