Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41618
Title: Altered profile of circulating endothelial-derived microparticles in ventilator-induced lung injury
Authors: Cabrera-Benítez, Nuria E.
Valladares, Francisco
García-Hernández, Sonia
Ramos-Nuez, Ángela
Martín Barrasa, José Luis 
Martínez-Saavedra, María-Teresa
Rodríguez-Gallego, Carlos 
Muros, Mercedes
Flores, Carlos
Liu, Mingyao
Slutsky, Arthur S.
Villar, Jesús
UNESCO Clasification: 320508 Enfermedades pulmonares
Issue Date: 2015
Journal: Critical Care Medicine 
Abstract: Pulmonary endothelial cell injury is central to the pathophysiology of acute lung injury. Mechanical ventilation can cause endothelial disruption and injury, even in the absence of preexisting inflammation. Platelet-endothelial cell adhesion molecule-1 is a transmembrane protein connecting adjacent endothelial cells. We hypothesized that injurious mechanical ventilation will increase circulating lung endothelial-derived microparticles, defined as microparticles positive for platelet-endothelial cell adhesion molecule-1, which could serve as potential biomarkers and mediators of ventilator-induced lung injury.
URI: http://hdl.handle.net/10553/41618
ISSN: 1530-0293
DOI: 10.1097/CCM.0000000000001280
Source: Critical Care Medicine [ISSN 1530-0293], v. 43 (12), e551-559. Erratum in: Crit Care Med. 2016 Mar;44(3):e180
URL: https://api.elsevier.com/content/abstract/scopus_id/84947210564
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