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http://hdl.handle.net/10553/41618
Title: | Altered profile of circulating endothelial-derived microparticles in ventilator-induced lung injury | Authors: | Cabrera-Benítez, Nuria E. Valladares, Francisco García-Hernández, Sonia Ramos-Nuez, Ángela Martín Barrasa, José Luis Martínez-Saavedra, María-Teresa Rodríguez-Gallego, Carlos Muros, Mercedes Flores, Carlos Liu, Mingyao Slutsky, Arthur S. Villar, Jesús |
UNESCO Clasification: | 320508 Enfermedades pulmonares | Issue Date: | 2015 | Journal: | Critical Care Medicine | Abstract: | Pulmonary endothelial cell injury is central to the pathophysiology of acute lung injury. Mechanical ventilation can cause endothelial disruption and injury, even in the absence of preexisting inflammation. Platelet-endothelial cell adhesion molecule-1 is a transmembrane protein connecting adjacent endothelial cells. We hypothesized that injurious mechanical ventilation will increase circulating lung endothelial-derived microparticles, defined as microparticles positive for platelet-endothelial cell adhesion molecule-1, which could serve as potential biomarkers and mediators of ventilator-induced lung injury. | URI: | http://hdl.handle.net/10553/41618 | ISSN: | 1530-0293 | DOI: | 10.1097/CCM.0000000000001280 | Source: | Critical Care Medicine [ISSN 1530-0293], v. 43 (12), e551-559. Erratum in: Crit Care Med. 2016 Mar;44(3):e180 | URL: | https://api.elsevier.com/content/abstract/scopus_id/84947210564 |
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