Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/37101
Title: Cytotoxic compounds derived from marine sponges. A Review (2010-2012)
Authors: Mioso, Roberto 
Toledo-Marante, Francisco J. 
De Souza Bezerra, Ranilson
Pereira Borges, Flavio Valadares
De Oliveira Santos, Barbara V.
Herrera Bravo de Laguna, Irma 
UNESCO Clasification: 2401 Biología animal (zoología)
3209 Farmacología
Keywords: Porifera
Marine sponges
Pharmacology
Bioactive molecules
Cytotoxicity, et al
Issue Date: 2017
Journal: Molecules 
Abstract: This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida. Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation.
URI: http://hdl.handle.net/10553/37101
ISSN: 1420-3049
DOI: 10.3390/molecules22020208
Source: Molecules,v. 22 (208)
Appears in Collections:Reseña
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